PMID: 11902652Mar 21, 2002Paper

Synthesis of variously 9,9-dialkylated octahydropyrimido [3,4-a]-s-triazines with potential antifungal activity

Il Farmaco
Amar GhaibO Lafont

Abstract

9,9-Dialkyloctahydropyrimido[3,4-a]-s-triazines were synthesized by iminodimethylation reaction between a 5,5-dialkyl-6-aminopyrimidine-2.4(3H,5H)-dione, a substituted aniline and two moles of formaldehyde. The synthesis of.5,5-dialkyl-6-aminopy-rimidinedione consisted of the condensation of urea with ethyl 2,2-dialkylcyanoacetates. 18 Octahydropyrimido[3,4-a]-s-triazines were synthesized and compounds resulting from a supplementary aminomethylation were also obtained. Most of these compounds were tested for antifungal activity in vitro. Only 9.9-dibutyl-6,8-dioxo-3(2-chlorophenyl)2,3,4,5,6,7,8,9-octahydropyrimido[3,4-a]-s-triazine showed some activity against Microsporum canis.

Citations

Apr 1, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Derek J ReidJennifer Scott
Sep 15, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sherine N KhattabFernando Albericio
Feb 3, 2005·Bioorganic & Medicinal Chemistry Letters·K SrinivasU S N Murty
Jul 4, 2006·European Journal of Medicinal Chemistry·K SrinivasV Jayathirtha Rao

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