Synthesis of Y-Shaped OEGylated Poly(amino acid)s: The Impact of OEG Architecture

Biomacromolecules
Shixue WangXianhong Wang

Abstract

OEGylation is an attractive approach to modifying poly(amino acid)s. OEG conjugation improves water-solubility of poly(amino acid)s, and confers possible thermal-responsive functionality for the conjugated poly(amino acid)s. Nevertheless, the impact of OEG architecture and the manner in which the OEG moiety interferes with the performances of poly(amino acid)s remain a work in progress. In this study, a series of new linear and Y-shaped OEG-substituted poly(glutamic acid)s were designed and synthesized. It is found that the thermoresponsive behavior of OEGylated poly(glutamic acid)s experiences steric repulsion effect, the strengths of which are architecture and length-dependent, and grows pronounced only when the number of the OEG units is ≥6. Notably, the Y-shaped architecture is able to stabilize the helicity of poly(glutamic acid) backbones, while maintaining higher α-helical conformation than its linear counterparts. In sum, our result indicate that Y-shaped architecture is more appropriate toward OEGylating poly(amino acid)s for biomedical applications.

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Citations

Jun 23, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chenglong GeLichen Yin
Nov 24, 2020·Macromolecular Rapid Communications·Yue Tao, Youhua Tao
Jun 3, 2021·Polymers·Chao GengHongda Wang
Jul 15, 2020·The Journal of Organic Chemistry·Yeting Zheng, Angel E Kaifer

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