Synthesis, selective anti-Helicobacter pylori activity, and cytotoxicity of novel N-substituted-2-oxo-2H-1-benzopyran-3-carboxamides

Bioorganic & Medicinal Chemistry Letters
Franco ChimentiFrancesca Sisto

Abstract

N-substituted-3-carboxamido-coumarin derivatives were prepared and evaluated for selective antibacterial activity against 20 isolates of Helicobacter pylori clinical strains, including five metronidazole resistant ones. Some of them possessed the best activity against H. pylori metronidazole resistant strains with MIC values lower than the drug reference (metronidazole). Furthermore, anti-inflammatory activity through the inhibition of the IL-8 production was investigated.

Citations

May 25, 2013·European Journal of Medicinal Chemistry·Simone CarradoriBruna Bizzarri
Sep 20, 2011·Journal of Medicinal Chemistry·Maria J MatosDolores Viña
Feb 2, 2016·European Journal of Medicinal Chemistry·Charlotte BouckaertLionel Pochet
Mar 22, 2016·Journal of Chemical Information and Modeling·Gloria MazzoneNino Russo
Mar 31, 2016·The Journal of Antibiotics·Karolina KlesiewiczNatalia Szkaradek
Jun 27, 2015·European Journal of Medicinal Chemistry·Rangappa S KeriM Amélia Santos
Jul 29, 2017·Journal of Medicinal Chemistry·André FonsecaFernanda Borges
Nov 29, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Souad BouaslaFrancisco J Romero-Salguero
Jul 8, 2015·Natural Product Reports·Fernanda G MedinaSoraya Osegueda-Robles
Sep 12, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Pen-Yuan LinLin-Wen Lee
Jan 5, 2018·Anti-cancer Agents in Medicinal Chemistry·Saleem FarooqS Koul
Apr 22, 2011·Organic & Biomolecular Chemistry·Marta CostaFernanda Proença
Aug 22, 2020·Future Medicinal Chemistry·Claudia Ta PiresRosilene F Cardoso
Jan 19, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Joana AraújoMaria Elizabeth Tiritan
Aug 25, 2016·Acta Crystallographica. Section E, Crystallographic Communications·Lígia R GomesFernanda Borges
Oct 13, 2016·Magnetic Resonance in Chemistry : MRC·André FonsecaFernanda Borges
Aug 19, 2016·Acta Crystallographica. Section E, Crystallographic Communications·Lígia R GomesFernanda Borges
Sep 13, 2018·Medicinal Chemistry·Saleem FarooqSurrinder Koul
Jul 5, 2021·European Journal of Medicinal Chemistry·Elham GhobadiSaeed Emami

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.