Synthesis, solvatochromaticity and bioactivities of some transition metal complexes with 2-(R-benzylideneamino)-pyridin-3-ol Schiff base derivatives

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
I S Ahmed, M A Kassem

Abstract

New four Schiff bases are prepared by condensation of 2-amino-pyridin-3-ol with 3, 4-dihydroxy-benzaldehyde (I), 2-hydroxybenzaldehyde (II), 5-bromo-2-hydroxybenzaldehyde (III), and 4-dimethylaminobenzaldehyde (IV). The structures of these compounds are characterized based on elemental analyses (C. H. N), IR and (1)H NMR. Also, the electronic absorption spectra are recorded in organic solvents of different polarity. The solvents are selected to be covered a wide range of parameters (refractive index, dielectric constant and hydrogen bonding capacity). The UV-vis absorption spectra of Schiff base compounds are investigated in aqueous buffer solutions of varying pH and utilized for the determination of ionization constant, pK(a) and activation free energy, DeltaG(*) of the ionization process. The biological activity against bacterial species and fungi as microorganisms representing different microbial categories such as (two Gram-negative bacteria, Eschericha coli and Agrobacterium sp.),three Gram-positive bacteria (Staphylococcus aureus, Bacillus subtlus and Bacillus megatherium), yeast (Candida albicans), and fungi (Aspergillus niger) were studied.

References

Jan 14, 2005·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Ján VancoJindra Valentová
Jun 28, 2005·European Journal of Medicinal Chemistry·Bantwal Shivarama HollaNalilu Suchetha Kumari
Apr 1, 2006·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Gehad G Mohamed
Nov 17, 2007·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ali Akbar KhandarZolfaghar Rezvani

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