Synthesis, spectral characterization and larvicidal activity of acridin-1(2H)-one analogues

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
R SubashiniPavan Kumar Gullanki

Abstract

Acridin-1(2H)-one analogue of 7-chloro-3,4-dihydro-9-phenyl-2-[(pyridine-2yl) methylene] acridin-1(2H)-one, 5 was prepared by using 7-chloro-3,4-dihydro-9-phenylacridin-1(2H)-one, 3 and picolinaldehyde, 4 in the presence of KOH at room temperature. These compounds were characterized by analytical and spectral analyses. The purpose of the present study was to assess the efficacy of larvicidal and repellent activity of synthesized 7-chloro-3,4-dihydro-9-phenyl-acridin-1(2H)-one analogues such as compounds 3 and 5 against the early fourth instar larvae of filariasis vector, Culex quinquefasciatus and Japanese encephalitis vector, Culex gelidus (Diptera: Culicidae). The compound exhibited high larvicidal effects at 50mg/L against both the mosquitoes with LC(50) values of 25.02 mg/L (r(2)=0.998) and 26.40 mg/L (r(2)=0.988) against C. quinquefasciatus and C. gelidus, respectively. The 7-chloro-3,4-dihydro-9-phenyl-acridin-1(2H)-one analogues that are reported for the first time to our best of knowledge can be better explored for the control of mosquito population. This is an ideal ecofriendly approach for the control of Japanese encephalitis vectors, C. quinquefasciatus and C. gelidus.

References

Apr 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G J FinlayB C Baguley
Jul 10, 2004·Insect Biochemistry and Molecular Biology·Janet HemingwayHilary Ranson

❮ Previous
Next ❯

Citations

May 29, 2014·BioMed Research International·A BharathiGovindasamy Rajakumar
Sep 23, 2014·Journal of Photochemistry and Photobiology. B, Biology·A BharathiG Rajakumar
Aug 5, 2016·Journal of Photochemistry and Photobiology. B, Biology·Makuteswaran SridharanMariadhas Valan Arasu
Dec 5, 2019·Current Drug Targets·Pone Kamdem Boniface, Ferreira Igne Elizabeth

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.