Synthesis, spectral studies and in vitro antibacterial activity of steroidal thiosemicarbazone and their palladium (Pd (II)) complexes

European Journal of Medicinal Chemistry
Salman Ahmad Khan, Mohamad Yusuf

Abstract

We investigated the antibacterial activity of some new steroidal thiosemicarbazone and their Pd(II) metal complexes. Metal complexes were prepared from the reaction of steroidal thiosemicarbazone with [Pd(DMSO)(2)Cl(2)]. Coordination via the thionic sulphur and the azomethine nitrogen atom of the thiosemicarbazone to the metal ion, the thiosemicarbazone derivatives were obtained by the thiosemicarbazide with steroidal ketones. All the compounds have been confirmed by spectral data. The antibacterial activity of these compounds was first tested in vitro by the disk diffusion assay against two gram-positive and two gram-negative bacteria, and then the minimum inhibitory concentration (MIC) was determined. The results showed that steroidal complexes are better inhibit growth as compared to steroidal thiosemicarbazones of both types of the bacteria (gram-positive and gram-negative); compound Ia is better antibacterial agent as compared to amoxicillin.

Citations

Aug 13, 2013·Chemical Reviews·Franck Le Bideau, Samuel Dagorne
Dec 5, 2015·Bioinorganic Chemistry and Applications·Yanmin HuangJianguo Cui
Dec 3, 2014·Steroids·Figueroa-Valverde LauroSarabia-Alcocer Bety
Apr 15, 2017·Bioorganic & Medicinal Chemistry Letters·Eugene M H YeeNaresh Kumar
Apr 22, 2020·Journal of Biochemical and Molecular Toxicology·Mediha Süleymanoğluİlhan Yaylım
May 7, 2021·Acta Crystallographica. Section E, Crystallographic Communications·Enis Nadia Md YusofEdward R T Tiekink

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