Synthesis, Spectroscopic, and Anticancerous Properties of Mixed Ligand Palladium(II) and Silver(I) Complexes with 4,6-Diamino-5-hydroxy-2-mercaptopyrimidine and 2,2'-Bipyridyl.

Metal-based Drugs
Sahar I Mostafa, Farid A Badria

Abstract

Synthesis of two new water-soluble mixed ligand [Pd(bpy)(dahmp)]Cl and [Ag(bpy)(Hdahmp)]NO(3) complexes (dahmp and Hdahmp are the deprotonated monoanion and the protonated neutral 4,6-diamino-5-hydroxy-2-mercaptopyrimidine, resp.) is reported. The composition of the reported complexes was discussed on the bases of IR, (1)H NMR, and mass spectra, as well as conductivity and thermal measurements. The reported complexes display a significant anticancer activity against Ehrlich ascites tumor cells (EACs). The higher activity of these complexes with their higher conductivity values corresponds to their complete ionization in aqueous solution.

References

Jan 1, 1978·Biochemical Pharmacology·B ArdalanP S Schein
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F P HarmersJ P Neijt
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P RougierP H Lasser
Jan 1, 1967·Psychologische Forschung·R Bergius
Sep 1, 1967·British Journal of Pharmacology and Chemotherapy·V N KrishnamurthyH B Praphulla
Sep 1, 1967·British Journal of Pharmacology and Chemotherapy·F H SchneiderH Winkler
Apr 1, 1994·Planta medica·P Sur, D K Ganguly
Feb 19, 1993·Journal of Medicinal Chemistry·M ColucciaG Natile
Jan 20, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D Lebwohl, R Canetta
Jan 1, 1954·Advances in Cancer Research·C OBERLING, M GUERIN
Apr 19, 2007·Chemistry, an Asian Journal·Dirk HollmannMatthias Beller

❮ Previous
Next ❯

Citations

Apr 25, 2013·Metallomics : Integrated Biometal Science·Christina N Banti, Sotiris K Hadjikakou
Mar 12, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·Piotr SmoleńskiAlexander M Kirillov
Nov 17, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hellen Franciane Gonçalves BarbosaÉder Tadeu Gomes Cavalheiro
Apr 24, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Alice JohnsonKogularamanan Suntharalingam
Dec 25, 2019·International Journal of Biological Macromolecules·Hellen Franciane Gonçalves BarbosaÉder Tadeu Gomes Cavalheiro

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.