Synthesis, spectroscopy, and biological properties of vanadium(IV)-hydrazide complexes

Chemistry & Biodiversity
Uzma AshiqMuhammad Iqbal Choudhary

Abstract

The synthesis, spectroscopic, enzyme-inhibition, and free-radical-scavenging properties of a series of vanadium(IV) complexes, compounds 1-10, were investigated. These complexes exhibit a dimeric structure with hydrazide ligands coordinated in a bidentate fashion. All complexes are stable in the solid state, but exhibit varying degrees of stability in solution. In coordinating solvent such as DMSO, stepwise binding of two solvent molecules at the 6th positions trans to the V double bond O bond of the dimeric unit is observed. The dimeric compounds are converted to monomeric species in which both solvent molecules and the hydrazide ligands are coordinated to the V(IV) center. The free hydrazide ligands 11-20 were inactive against alpha-glucosidase, but the V(IV) complexes showed varying degrees of inhibition, depending on the type of ligand. The DPPH-radical-scavenging activities of 1-20 were determined, which indicated that steric and/or electronic effects responsible for changes in geometry play important roles in terms of antioxidant potential.

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Citations

Jan 1, 2008·Acta Crystallographica. Section E, Structure Reports Online·Rifat Ara JamalIslam Ullah Khan
Jan 1, 2009·Acta Crystallographica. Section E, Structure Reports Online·Uzma AshiqIslam Ullah Khan
Jan 1, 2009·Acta Crystallographica. Section E, Structure Reports Online·Rifat Ara JamalIslam Ullah Khan
Jan 1, 2009·Acta Crystallographica. Section E, Structure Reports Online·Uzma AshiqIslam Ullah Khan
Jan 1, 2009·Acta Crystallographica. Section E, Structure Reports Online·Rifat Ara JamalIslam Ullah Khan
Jan 1, 2010·Acta Crystallographica. Section E, Structure Reports Online·Uzma AshiqIslam Ullah Khan
Feb 12, 2009·Chemical Biology & Drug Design·Xing-Hai LiuZheng-Ming Li
Oct 11, 2017·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Sadaf SultanLubna Iqbal
Nov 19, 2020·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Bonisiwe MbathaPhikelelani Ngubane
Jul 14, 2021·Critical Reviews in Food Science and Nutrition·Chunhua ZhangChunpeng Wan

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