PMID: 12763651May 24, 2003Paper

Synthesis, structure and nuclease properties of several ternary copper(II) peptide complexes with 1,10-phenanthroline

Journal of Inorganic Biochemistry
A García-RasoE Molins

Abstract

Three new ternary peptide-Cu(II)-1,10-phenanthroline (phen) complexes, [Cu(L-ala-gly)(phen)].3.5H(2)O 1, [Cu(L-val-gly)(phen)] 2 and [Cu(gly-L-trp)(phen)].2H(2)O 3, have been prepared and structurally characterised. These compounds exist as distorted square pyramidal complexes with the five co-ordination sites occupied by the tridentate peptide dianion and the two heterocyclic nitrogens of the phenanthroline ligand. The bulk of the lateral chain in the peptide moiety determines the relative disposition of the phen ligand. Thus, in [Cu(L-val-gly)(phen)] 2, the phenanthroline plane is deviated towards the opposite side of the isopropyl group of the L-valine moiety. On the other hand, in [Cu(gly-L-trp)(phen)].2H(2)O 3 the absence of stacking interactions between phen and indole rings and the presence of an intramolecular CH...pi interaction should be pointed out. These complexes exhibit significant differences in their nuclease activity which depends on the nature of the peptidic moiety, the complex [Cu(gly-L-trp) (phen)].2H(2)O 3 being the most active.

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Citations

Apr 20, 2016·Journal of Fluorescence·Rabindra Reddy PulimamidiSatyanarayana Battu
Mar 23, 2013·Journal of Photochemistry and Photobiology. B, Biology·Farukh ArjmandD K Mohapatra
Apr 19, 2005·Journal of Inorganic Biochemistry·Lian-Zhi LiHui Chao
Dec 10, 2017·Chemistry : a European Journal·Rong-Kai LinChu-Chieh Lin
Jul 20, 2007·Chemistry & Biodiversity·Pulimamidi R ReddyKarnati V G Reddy
Aug 3, 2005·Dalton Transactions : an International Journal of Inorganic Chemistry·Ashis K PatraAkhil R Chakravarty
Dec 29, 2006·Chemistry & Biodiversity·Pulimamidi R ReddySepuru K Mohan
Dec 29, 2006·Chemistry & Biodiversity·Pulimamidi R Reddy, Kandibanda S Rao
Dec 29, 2006·Chemistry & Biodiversity·Pulimamidi R ReddyKandibanda S Rao
Jan 31, 2009·Chemistry & Biodiversity·Pulimamidi R Reddy, Pallerla Manjula
Feb 24, 2005·Dalton Transactions : an International Journal of Inorganic Chemistry·Ashis K PatraAkhil R Chakravarty
Jan 16, 2007·Journal of Inorganic Biochemistry·Benigno MacíasAlfonso Castiñeiras
Jan 17, 2013·The Journal of Physical Chemistry. B·Chunmei LiuMingsheng Tang
Dec 1, 2005·Journal of the American Chemical Society·Lauren A LevineMary Elizabeth Williams

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