Synthesis, structure, and physicochemical properties of dinuclear NiII complexes as highly efficient functional models of phosphohydrolases

Inorganic Chemistry
Alessandra GreattiAdemir Neves

Abstract

As metal ions are present in the catalytic sites of several enzymes, attention has been focused on the synthesis and characterization of metal complexes able to act as biomimetic functional and structural models for these systems. In this study, a novel dinuclear NiII complex was synthesized, [Ni2(L2)(OAc)2(CH3CN)]BPh4 (2) (HL2=2-[N-(2-(pyridyl-2-yl)ethyl)(1-methylimidazol-2-yl)amin omethyl]-4-methyl-6-[N-(2-(imidazol-4-yl)ethyl)amino methyl]phenol), employing a new unsymmetrical dinucleating ligand containing N,O-donor groups as a model for hydrolases. Complex 2 was characterized by a variety of techniques including: elemental analysis, infrared and UV-vis spectroscopies, molar conductivity, electrochemistry, potentiometric titration, magnetochemistry, and single-crystal X-ray diffractometry. The structural and magnetochemical data of 2 allow us to consider this complex as a structural model for the active site of the ureases, as previously reported for [Ni2(L1)(OAc)2(H2O)]ClO4.H2O (1) (HL1=2-[N-bis-(2-pyridylmethyl)aminomethyl]-4-methyl-6-[N-(2-pyridylmethyl)aminomethyl] phenol). The characterization of complexes 1 and 2 (mainly by X-ray diffraction and potentiometric titration) led us to study their reactivities toward the h...Continue Reading

References

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Citations

Jan 1, 2009·Acta Crystallographica. Section E, Structure Reports Online·Ai-Zhi Wu, Seik Weng Ng
Apr 2, 2017·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Bin XuZheng Xiang
Jun 1, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Panagiota S PerlepeTheocharis C Stamatatos
Aug 5, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·Martin JarenmarkEbbe Nordlander
Aug 4, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Pankaj KumarBiplab Mondal
Aug 22, 2018·Inorganic Chemistry·Nityananda DuttaManindranath Bera

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