Synthesis, structure, DNA-binding properties, and cytotoxicity of ruthenium(II) polypyridyl complexes

Chemistry & Biodiversity
Yun-Jun LiuHong-Liang Huang

Abstract

Many ruthenium(II) complexes show high antitumor activities, and the in vitro antitumor activities are usually related to DNA binding. We designed and synthesized two Ru(II) polypyridyl complexes, [Ru(dmp)2(fpp)]2+ (dmp=2,9-dimethyl-1,10-phenanthroline; fpp=2-[3,4-(difluoromethylenedioxy)phenyl]imidazo[4,5-f] [1,10]phenanthroline and [Ru(phen)(2)(fpp)]2+ (phen=1,10-phenanthroline). The DNA-binding properties of these complexes have been investigated by spectroscopic titration, DNA melting experiments, viscosity measurements, and photoactivated cleavage. The mechanism studies of photocleavage revealed that singlet oxygen (1O2) and superoxide anion radical (O2(.-)) may play an important role in the photocleavage. The cytotoxicity of complexes 1 and 2 have been evaluated by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide) method; complex 2 shows slightly higher anticancer potency than 1 does against all the cell lines screened.

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Citations

Mar 13, 2014·Journal of Photochemistry and Photobiology. B, Biology·A SrishailamS Satyanarayana
Mar 8, 2016·Journal of Photochemistry and Photobiology. B, Biology·Shang-Hai LaiYun-Jun Liu
Aug 16, 2016·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Maja NešićMarijana Petković
Oct 29, 2014·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Jaroslav VarcholaGregor Bánó

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