Synthesis, structures, and electrochemistry of gold(III) ethylenediamine complexes and interactions with guanosine 5'-monophosphate

Inorganic Chemistry
Shourong ZhuJ A Walmsley

Abstract

[Au(en)Cl(2)]Cl.2H(2)O, where en = ethylenediamine (1,2-diaminoethane), has been synthesized, and its structure has been solved for the first time by the single-crystal X-ray diffraction method. The complex has square-planar geometry about Au(III), and the anionic Cl- is located in the apical position and at a distance of 3.3033(10) A compared to 2.2811(9) and 2.2836(11) A for the coordinated Cl-. [Au(en)Cl2]Cl.2H2O belongs to the space group Pbca with a = 11.5610(15) A, b = 12.6399(17) A, c = 13.2156(17) A, alpha = beta = gamma = 90 degrees , and Z = 8. Bond lengths of Au-N are 2.03 A. [Au(en)Cl2]Cl.2H2O is less thermally stable than [Au(en)2]Cl3 because of the replacement of two Cl ligands by a second en ligand in the latter. Cyclic voltammetry shows that the formal potential of Au(III)/Au(0) becomes more negative in the series [AuCl4]-, [Au(en)Cl2]+, and [Au(en)2]3+. 1H, 13C, and 31P NMR reveal that in an aqueous solution [Au(en)Cl2]+ bonds to guanosine 5'-monophosphate, 5'-GMP (1:1 mole ratio), via N7, although the stability is not very high. NMR data also indicate that N7-O6 or N7-phosphate 5'-GMP chelation, as found in some gold(III) nucleotide complexes, is not present. The gold(III) complex undergoes hydrolysis at pH >2...Continue Reading

References

Sep 28, 1971·Biochemistry·D W GibsonR J Barrnett
Sep 28, 1971·Biochemistry·H A BertrandB P Yu
Apr 5, 2002·Journal of Medicinal Chemistry·Giordana MarconGiovanni Minghetti
Aug 28, 2003·Current Opinion in Chemical Biology·Christiana Xin Zhang, Stephen J Lippard
Mar 28, 2008·Bioinorganic Chemistry and Applications·Luigi MessoriPierluigi Orioli

❮ Previous
Next ❯

Citations

Jul 19, 2014·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Said S Al-JaroudiAnvarhusein A Isab
Dec 11, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Yousef FazaeliHossein Afarideh
May 23, 2012·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Slobodan M JankovićDragan Canović
May 1, 2009·Journal of Chemical Crystallography·D Michelle MotleyEdward R T Tiekink
Aug 13, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Takuya FujimuraShinsuke Takagi
Mar 18, 2017·Chemical Communications : Chem Comm·Andreia de AlmeidaAngela Casini
Jan 19, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·R Tyler MertensSamuel G Awuah
Aug 28, 2019·Scientific Reports·Jong Hyun KimSamuel G Awuah
Feb 27, 2020·Chemical Communications : Chem Comm·Angel TerrónAntonio Frontera
Jul 7, 2017·Journal of Inorganic Biochemistry·Katherine W PulsipherIvan J Dmochowski
Jul 30, 2014·ACS Applied Materials & Interfaces·Taegeon KimSeung Min Han
Feb 20, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Defu Liang, Giovanni Zangari

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.