Synthesis, structures and in vitro cytotoxicity of some platinum(II) complexes containing thiocarbamate esters

Journal of Inorganic Biochemistry
Daniel DolfenFabian Mohr

Abstract

The thiocarbamate esters 4-RC6H4NHC(S)OMe (R = H, Cl, OMe, NO2, Me) react with cis-[PtCl2(PTA)2] (PTA=1,3,5-triaza-7-phosphaadamantane) in the presence of base to afford the platinum(II) complexes trans-[Pt{SC(OMe)NC6H4R}2(PTA)2] (R=H, Cl, OMe, NO2, Me) in high yields. The complexes were fully characterised spectroscopically and, in case of the NO2 derivate, by X-ray crystallography. Cytotoxicity of these complexes was studied in vitro in four human cancer cell lines (CH1, HT29, A549, SK-OV-3) using the MTT assay. The results show that the Cl substituted derivate is the most potent of these compounds in vitro. Moreover, this derivative is capable of partially circumventing primary cisplatin resistance in ovarian and colon carcinoma cells.

References

Feb 3, 2007·Anti-cancer Agents in Medicinal Chemistry·Mauro Coluccia, Giovanni Natile

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Citations

Mar 22, 2018·Dalton Transactions : an International Journal of Inorganic Chemistry·Anja MolterFabian Mohr
Dec 9, 2017·Chemistry : a European Journal·Elena LalindeSergio Piñeiro-Hermida
Dec 22, 2009·Dalton Transactions : an International Journal of Inorganic Chemistry·Esther SchuhFabian Mohr
Sep 1, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Anja MolterFabian Mohr

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