Synthesis, swelling behavior, and biocompatibility of novel physically cross-linked polyurethane-block-poly(glycerol methacrylate) hydrogels

Biomacromolecules
Kibret MequanintDeon Bezuidenhout

Abstract

Physically cross-linked novel block copolymer hydrogels with tunable hydrophilic properties for biomedical applications were synthesized by controlled radical polymerization of polyurethane macroiniferter and (2,2-dimethyl-1,3-dioxolane) methyl methacrylate. The block copolymers were converted to hydrogels by the selective hydrolysis of poly[(2,2-dimethyl-1,3-dioxolane) methyl methacrylate] block to poly(glycerol methacrylate). The block copolymerization has been monitored by monomer conversion and molecular weight increase as a function of time. It was observed that the polymerization proceeded with a characteristic "living" behavior where both monomer conversion and molecular weight increased linearly, with increasing reaction time. The resulting hydrogels were investigated for their equilibrium water content (EWC), dynamic water contact angles, swelling kinetics, thermodynamic interaction parameters, plasma protein adsorption, and platelet adhesion. Similar to our previous mechanically responsive hydrogels (Mequanint, K.; Sheardown, H. J. Biomater. Sci. Polym. Ed. 2005, 10, 1303-1318), the present results indicated that block copolymer hydrogels have excellent hydrophilicity and swelling behavior with improved modulus of ela...Continue Reading

Citations

Dec 29, 2013·Journal of Colloid and Interface Science·Haritz EtxeberriaGalder Kortaberria
Mar 23, 2011·Journal of Biomaterials Science. Polymer Edition·Goutam ThakurAmit Basak
Oct 13, 2007·Journal of Biomaterials Science. Polymer Edition·Sara AlibeikKibret Mequanint
Mar 18, 2010·Journal of Biomaterials Science. Polymer Edition·Dechuang YuanCan Zhang
May 29, 2010·Journal of Biomaterials Science. Polymer Edition·Jinku XuPeiting Cao
Jul 24, 2012·Biomaterials·Banani Kundu, Subhas C Kundu
Apr 26, 2007·Macromolecular Bioscience·Alpesh Patel, Kibret Mequanint
Feb 6, 2009·Biotechnology Progress·Andrew J Daugulis
Sep 20, 2012·International Journal of Pharmaceutics·Mariano LicciardiGaetano Giammona
Aug 12, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Wenbo ZhaoXiaohua Huang
Dec 7, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Nozomi ItagakiKeiji Tanaka

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