Synthesized Au NPs@silica composite as surface-enhanced Raman spectroscopy (SERS) substrate for fast sensing trace contaminant in milk

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Yi XuQuansheng Chen

Abstract

With increased concerns on milk safety issues, the development of a simple and sensitive method to detect 2,4-dichlorophenoxyacetic acid (2,4-D), a common contaminant in milk, becomes relevant in safeguarding human health threats that results from its consumption. Surface-enhanced Raman spectroscopy (SERS) shows excellent ability for various targets analysis but its usage for rapid and accurate determination of analyte via SERS presents challenges. This study attempted the quantification of 2,4-dichlorophenoxyacetic acid (2,4-D) residue in milk using a novel SERS active substrate- decorated silica films with Au nanoparticles (Au NPs@ silica) coupled to chemometric algorithms. Au NPs@ silica composite was synthesized as a SERS sensor through self-assembly. Thereafter, the SERS spectrum of 2,4-D extract from milk with different concentrations based on the developed SERS sensor was collected and the spectra were analyzed by partial least squares (PLS), and variable selection algorithms - genetic algorithm-PLS (GA-PLS), competitive-adaptive reweighted sampling-PLS (CARS-PLS) and ant colony optimization-PLS (ACO-PLS), to develop quantitative models for 2,4-D prediction. The results obtained showed that the CARS-PLS model gave the op...Continue Reading

Citations

Nov 30, 2020·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Md Mehedi HassanQuansheng Chen
Jan 6, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Xiaoyu ZhuShirong Ai
Dec 19, 2021·Analytical Chemistry·Dana Cialla-MayJürgen Popp

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