Synthetic analogs of growth hormone-releasing factor with antagonistic activity in vitro

Biochemical and Biophysical Research Communications
K SatoN Ling

Abstract

Analogs of human and rat growth hormone-releasing factor (hGRF and rGRF), related to [D-Arg2]hGRF(1-29)NH2, were synthesized by solid phase methodology. Their capacity to inhibit growth hormone secretion stimulated by hGRF(1-44)NH2 was tested on rat anterior pituitary cells in monolayer culture. Among the analogs of hGRF, [D-Arg2,29,Arg30]hGRF(1-30)NH2 showed the highest antagonistic potency of 3.64 relative to [D-Arg2]hGRF(1-29)NH2 = 1. However, the most potent analog synthesized thus far was [N-Ac-His1,D-Arg2,Ala15]rGRF(1-29)NH2, which showed a relative potency of 27.7.

References

Feb 1, 1985·Journal of Medicinal Chemistry·D H CoyV A Lance
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·P BrazeauR Guillemin
Oct 31, 1983·Biochemical and Biophysical Research Communications·P BöhlenR Guillemin
Dec 28, 1983·Biochemical and Biophysical Research Communications·F EschR Guillemin
Jul 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·N LingR Guillemin
Sep 17, 1984·Biochemical and Biophysical Research Communications·N LingP Brazeau
Dec 14, 1984·Biochemical and Biophysical Research Communications·P BrazeauR Guillemin

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Citations

Mar 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·Z Rekasi, A V Schally
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·M ZarandiA V Schally
Feb 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jozsef L VargaMarta Zarandi
Jan 20, 1999·Proceedings of the National Academy of Sciences of the United States of America·J L VargaZ Rékási
Mar 27, 1998·The Journal of Peptide Research : Official Journal of the American Peptide Society·K TothA V Schally

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