PMID: 16613573Apr 15, 2006Paper

Synthetic and natural coumarins as antioxidants

Mini Reviews in Medicinal Chemistry
Irena Kostova

Abstract

Coumarins, an old class of compounds, are naturally occurring benzopyrene derivatives. A lot of coumarins have been identified from natural sources, especially green plants. These natural compounds have served as valuable leads for further design and synthesis of more active analogs. The pharmacological and biochemical properties and therapeutic applications of simple coumarins depend upon the pattern of substitution. Coumarins have attracted intense interest in recent years because of their diverse pharmacological properties. Among these properties, their antioxidant effects were extensively examined. In this review, plant derived coumarins and their synthetic analogs will be systematically evaluated based on their plant origin, structure-activity relationship and antioxidant efficacy. Owing their diverse effects and inconclusive results from different in vitro studies, the mechanism of their action has not yet been fully understood and the correlation of effects with chemical structure is not conclusive at the moment. It is the objective of this review will be to summarize experimental data for different coumarins used as antioxidant agents, because promising data have been reported for a series of these agents. In addition, ...Continue Reading

Citations

Dec 18, 2013·Journal of Fluorescence·Krzysztof ŻamojćLech Chmurzyński
Dec 4, 2014·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Krzysztof ŻamojćLech Chmurzyński
Aug 12, 2014·Metabolic Brain Disease·Wojciech ŁuczajElżbieta Skrzydlewska
Jan 26, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yasameen K Al-MajedyAbu Bakar Mohamad
May 18, 2012·Journal of Enzyme Inhibition and Medicinal Chemistry·Michael G KallitsakisKonstantinos E Litinas
Aug 27, 2015·Journal of Enzyme Inhibition and Medicinal Chemistry·Belma Zengin KurtMustafa Kucukislamoglu
Sep 6, 2011·Bioorganic & Medicinal Chemistry Letters·Jigar A MakawanaRanjan G Patel
Sep 14, 2010·Journal of Pharmaceutical and Biomedical Analysis·Snjezana DragojevićIvica Malnar
Apr 20, 2010·Bioorganic & Medicinal Chemistry Letters·Koneni V SashidharaA K Khanna
Feb 4, 2010·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Irena Kostova, Tsvetanka Stefanova
Dec 11, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Elaheh MosaddeghHassan Karimi-Maleh
Jan 1, 2008·Environmental Toxicology and Pharmacology·Inas S GhalyMosaad A Abdel-Wahhab
Jul 24, 2007·Bioorganic & Medicinal Chemistry Letters·Kyoko Nakagawa-GotoKuo-Hsiung Lee
Nov 7, 2015·Bioorganic & Medicinal Chemistry Letters·Krishnaiah VaarlaMurali Krishna Toopurani
Dec 7, 2007·The Journal of Pharmacy and Pharmacology·Jens Z PedersenLuciano Saso
Jul 8, 2015·Natural Product Reports·Fernanda G MedinaSoraya Osegueda-Robles
Jun 9, 2012·European Journal of Medicinal Chemistry·Filipe AreiasMaría I Loza
Sep 22, 2012·Biochimie·Kateřina MacákováLuciano Saso
Jul 14, 2011·European Journal of Pharmacology·Judith SinghuberSteffen Hering
Oct 24, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Ismail Adam ArbabSiddig Ibrahim Abdelwahab
Jun 15, 2010·Bioorganic & Medicinal Chemistry Letters·Koneni V SashidharaA K Khanna
Jan 24, 2012·Bioorganic & Medicinal Chemistry·Nathaniel Edward Bennett SaiduMathias Montenarh
Jul 27, 2012·Bioorganic & Medicinal Chemistry Letters·Fernanda Pérez-CruzEugenio Uriarte
May 16, 2013·Bioorganic & Medicinal Chemistry·Maria João MatosClaudio Olea-Azar
Jan 10, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mariangela MarrelliFilomena Conforti
Oct 1, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·W LuczajE Skrzydlewska
Jun 14, 2016·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Mehrdad DadsetaniAbedin Zabardasti
Feb 2, 2008·Journal of Combinatorial Chemistry·Kelin Li, Jon A Tunge
Mar 7, 2017·Pharmaceutical Biology·Olufunke O FajinmiJohannes Van Staden
Feb 19, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maria J MatosClaudio Olea-Azar
Jan 21, 2020·Journal of Food Science·Seyed Mohammad AhmadiMitra Rezaie
Jan 1, 2016·Journal of Food and Drug Analysis·Hossein DehghanPeyman Salehi
Dec 17, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maria Graça Miguel
Jul 31, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Juliana Helena Castro E SilvaSilvia Lima Costa
Dec 15, 2007·The Journal of Organic Chemistry·Bartolo GabrielePierluigi Plastina

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