Synthetic Biology--Toward Therapeutic Solutions

Journal of Molecular Biology
Viktor Haellman, Martin Fussenegger

Abstract

Higher multicellular organisms have evolved sophisticated intracellular and intercellular biological networks that enable cell growth and survival to fulfill an organism's needs. Although such networks allow the assembly of complex tissues and even provide healing and protective capabilities, malfunctioning cells can have severe consequences for an organism's survival. In humans, such events can result in severe disorders and diseases, including metabolic and immunological disorders, as well as cancer. Dominating the therapeutic frontier for these potentially lethal disorders, cell and gene therapies aim to relieve or eliminate patient suffering by restoring the function of damaged, diseased, and aging cells and tissues via the introduction of healthy cells or alternative genes. However, despite recent success, these efforts have yet to achieve sufficient therapeutic effects, and further work is needed to ensure the safe and precise control of transgene expression and cellular processes. In this review, we describe the biological tools and devices that are at the forefront of synthetic biology and discuss their potential to advance the specificity, efficiency, and safety of the current generation of cell and gene therapies, inc...Continue Reading

References

Jun 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·M Gossen, H Bujard
Apr 1, 1995·Molecular and Cellular Biology·U DeuschleH J Thiesen
Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·T ClacksonD A Holt
Feb 1, 2002·Nature Biotechnology·Roger R Beerli, Carlos F Barbas
Nov 5, 2002·Nature Medicine·Edward J RebarFrank J Giordano
May 3, 2003·Nature Reviews. Genetics·Clare E ThomasMark A Kay
Jul 31, 2003·Biotechnology and Bioengineering·Beat P KramerMartin Fussenegger
Dec 24, 2003·Molecular Cell·Kryn StankunasGerald R Crabtree
Jan 17, 2004·Science·Utpal P DavéNeal G Copeland
Jun 9, 2004·Nature Biotechnology·Beat P KramerMartin Fussenegger
Sep 17, 2004·Nature·Victor Ambros
Feb 25, 2005·Blood·Karin C StraathofCliona M Rooney
Apr 20, 2005·Lancet·Robert H EckelPaul Z Zimmet
Jun 10, 2005·Microbiology and Molecular Biology Reviews : MMBR·Juan L RamosRaquel Tobes
Aug 17, 2005·Current Gene Therapy·James CroninJakob Reiser
Oct 19, 2005·Gene Therapy·R AlbaM Chillon
Jun 9, 2006·Nature Reviews. Neuroscience·Patrice G Guyenet
Nov 30, 2006·Annual Review of Immunology·Lisbeth A WelniakWilliam J Murphy
Dec 14, 2006·Molecular Therapy : the Journal of the American Society of Gene Therapy·Robert StraussAndré Lieber
Feb 14, 2007·Proceedings of the National Academy of Sciences of the United States of America·Wilfried WeberMartin Fussenegger
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Blaine N ArmbrusterBryan L Roth
Apr 28, 2007·Biotechnology and Bioengineering·Wilfried WeberMartin Fussenegger
May 23, 2007·Nature Biotechnology·Keller RinaudoYaakov Benenson
Aug 22, 2007·Proceedings of the National Academy of Sciences of the United States of America·Maung Nyan Win, Christina D Smolke
Jan 1, 2008·Proceedings of the National Academy of Sciences of the United States of America·Gilad BarneaKevin J Lee

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Citations

Feb 2, 2016·Journal of Molecular Biology·Timothy K LuHélène Hodak
Dec 26, 2015·Integrative Biology : Quantitative Biosciences From Nano to Macro·Anton DobrinMartin Fussenegger
Dec 18, 2015·Integrative Biology : Quantitative Biosciences From Nano to Macro·Carolyn ZhangLingchong You
Nov 15, 2017·Nature Communications·Jovan MirceticFrank Buchholz
Nov 14, 2017·Nature Chemical Biology·Ryosuke KojimaMartin Fussenegger
Oct 19, 2017·Advanced Healthcare Materials·Yi LiuGregory F Payne
May 11, 2019·Journal of Biological Engineering·C P Healy, T L Deans
Feb 1, 2020·Nature Communications·Krzysztof KrawczykMartin Fussenegger
Aug 5, 2017·Scientific Reports·Cordelia P N RampleyWei E Huang
Apr 24, 2019·Nature Biomedical Engineering·Ferdinand SedlmayerMartin Fussenegger
Apr 25, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Attila Becskei
Mar 20, 2018·Journal of Industrial Microbiology & Biotechnology·Mitchell S Weisenberger, Tara L Deans
Nov 26, 2021·Applied Microbiology and Biotechnology·Kanika BhargavaNeelam Jain

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