Synthetic biology evolves

Trends in Biotechnology
William J Blake, Farren J Isaacs

Abstract

Synthetic biology is advancing rapidly as biologists, physicists and engineers are combining their efforts to understand and program cell function. By characterizing isolated genetic components or modules, experimentalists have paved the way for more quantitative analyses of genetic networks. A recent paper presents a method of computational, or in silico, evolution in which a set of components can evolve into networks that display desired behaviors. An integrated approach that includes a strategy of in silico design by evolution, together with efforts exploiting directed evolution in vivo, is likely to be the next step in the evolution of synthetic biology.

References

Jun 29, 2000·Annual Review of Biochemistry·D S Wilson, J W Szostak
Apr 23, 2002·Nature Genetics·Ertugrul M OzbudakAlexander van Oudenaarden
Apr 23, 2002·Nature Genetics·Shai S Shen-OrrUri Alon
May 25, 2002·Science·Călin C GuetStanislas Leibler
Jul 27, 2002·Annual Review of Microbiology·Susan M Uptain, Susan Lindquist
Aug 17, 2002·Science·Michael B ElowitzPeter S Swain
Oct 26, 2002·Science·Tong Ihn LeeRichard A Young
Nov 27, 2002·Proceedings of the National Academy of Sciences of the United States of America·Yohei YokobayashiFrances H Arnold
Apr 11, 2003·Nature·William J BlakeJ J Collins
Jun 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Farren J IsaacsJ J Collins
Jan 6, 2004·Proceedings of the National Academy of Sciences of the United States of America·Paul François, Vincent Hakim
Jan 7, 2004·Nature Reviews. Genetics·Michael E WallMichael A Savageau
Jan 13, 2004·Science·Dan Ferber
Feb 20, 2004·Nature·Ertugrul M OzbudakAlexander Van Oudenaarden
Feb 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Thomas BulterJames C Liao

❮ Previous
Next ❯

Citations

Dec 26, 2006·Bio Systems·Soichiro TsudaYukio-Pegio Gunji
Jul 16, 2013·The Biochemical Journal·Betül Kaçar, Eric A Gaucher
Feb 14, 2012·Studies in History and Philosophy of Biological and Biomedical Sciences·Maureen A O'Malley, Orkun S Soyer
Sep 22, 2006·Systems Biology·S R PaladuguH M Sauro

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.