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Synthetic biology of secondary metabolite biosynthesis in actinomycetes: Engineering precursor supply as a way to optimize antibiotic production

FEBS Letters

Jun 20, 2012

W WohllebenT Weber

Abstract

Actinomycetes are a rich source for the synthesis of medically and technically useful natural products. The genes encoding the enzymes for their biosynthesis are normally organized in gene clusters, which include also the information for resistance (in the case of antibacterial compound...read more

Mentioned in this Paper

Vancomycin
Amycolatopsis orientalis
Metabolic Process, Cellular
5-dehydro-3-deoxy-D-arabino-heptulosonic acid-7-phosphate
Biochemical Pathway
Conjugation
Polyketide synthase
Derivatives
Enzymes, antithrombotic
Antibiotic throat preparations
5
140
Paper Details
References
  • References49
  • Citations20
12345
  • References49
  • Citations20
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Synthetic biology of secondary metabolite biosynthesis in actinomycetes: Engineering precursor supply as a way to optimize antibiotic production

FEBS Letters

Jun 20, 2012

W WohllebenT Weber

PMID: 22710162

DOI: 10.1016/j.febslet.2012.04.025

Abstract

Actinomycetes are a rich source for the synthesis of medically and technically useful natural products. The genes encoding the enzymes for their biosynthesis are normally organized in gene clusters, which include also the information for resistance (in the case of antibacterial compound...read more

Mentioned in this Paper

Vancomycin
Amycolatopsis orientalis
Metabolic Process, Cellular
5-dehydro-3-deoxy-D-arabino-heptulosonic acid-7-phosphate
Biochemical Pathway
Conjugation
Polyketide synthase
Derivatives
Enzymes, antithrombotic
Antibiotic throat preparations
5
140

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Artificial Cell Models

This feed focuses on biomimetrics, synthetic biology and bio- and tissue-engineering approaches used for modeling human diseases.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

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Methods in Enzymology

Chapter 18. Molecular genetic approaches to analyze glycopeptide biosynthesis

Methods in EnzymologyApril 21, 2009
Wolfgang WohllebenRoderich D Süssmuth
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Assembling the glycopeptide antibiotic scaffold: The biosynthesis of A47934 from Streptomyces toyocaensis NRRL15009

Proceedings of the National Academy of Sciences of the United States of AmericaJune 13, 2002
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Paper Details
References
  • References49
  • Citations20
12345
  • References49
  • Citations20
12
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