PMID: 6975766Sep 1, 1981Paper

Synthetic C3a analogs as specific inhibitors of C3a activity

Immunopharmacology
S MeuerD Bitter-Suermann

Abstract

Various C3a-related C-terminal synthetic oligopeptides were investigated for their ability to induce a release of serotonin from guinea pig platelets. The results confirm earlier findings that expression of biological C3a activity requires the four to five C-terminal amino acids of the C3a primary structure and underlines the essential role of the C-terminal arginine. Besides their ability to induce a specific release reaction, these peptides--after short incubation with the platelets--lead to a specific desensitization of the cells for C3a or C3a-related stimuli. Expression of this inhibitory activity required concentrations of the peptides more than 100-fold lower than those that were necessary to induce secretion. The possibility of using C3a analogs as specific inhibitors for C3a offers a valuable tool for in vivo studies of biological C3a activity.

References

May 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·T E Hugli, B W Erickson
Jan 1, 1978·Scandinavian Journal of Immunology·S BeckerD Bitter-Suermann
Jan 1, 1978·Scandinavian Journal of Immunology·S BeckerD Bitter-Suermann

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Citations

Nov 15, 1992·European Journal of Biochemistry·T KretzschmarJ Köhl
Jun 1, 1989·European Journal of Immunology·R Gerardy-SchahnD Bitter-Suermann
Jun 15, 1982·Biochemical and Biophysical Research Communications·H J ShowellE J Corey
Apr 1, 1993·International Journal of Peptide and Protein Research·M PohlH Höcker

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