Synthetic cannabinoid 3-benzyl-5-[1-(2-pyrrolidin-1-ylethyl)-1H-indol-3-yl]-1,2,4-oxadiazole. The first detection in illicit market of new psychoactive substances

Forensic Science International : Synergy
Vadim ShevyrinYuri Morzherin

Abstract

We were the first to detect 3-benzyl-5-[1-(2-pyrrolidin-1-ylethyl)-1H-indol-3-yl]-1,2,4-oxadiazole (given name BzODZ-EPyr) as a new synthetic cannabinoid, in illegal market of new psychoactive compounds (NPS). The compound was known only from pharmaceutical literature so far. BzODZ-EPyr was identified by means of gas chromatography/mass spectrometry (GC/MS) including high resolution mass spectrometry (GC/HRMS), ultra-high performance liquid chromatography/high resolution tandem mass spectrometry (UHPLC/HRMS(2)), Fourier-transform infrared spectroscopy (FT-IR) and nuclear magnetic resonance spectroscopy (NMR) (1)H and (13)C. The peculiarities of mass-spectral fragmentation in experiments in electronic ionization (EI) and collision-induced dissociation (CID) modes were studied. Herewith we report analytical characteristics of BzODZ-EPyr enabling its (and possible analogues thereof) determination in criminal seizures.

References

Jun 22, 2007·European Journal of Medicinal Chemistry·Gerard P MoloneyArthur Christopoulos
Feb 2, 2010·Forensic Science International : Synergy·Nahoko UchiyamaYukihiro Goda
Apr 5, 2013·ACS Chemical Neuroscience·Samuel D BanisterMichael Kassiou
Sep 24, 2013·Forensic Science International : Synergy·Vadim ShevyrinYuri Shafran
Sep 16, 2014·Drug and Alcohol Dependence·Marisol S CastanetoMarilyn A Huestis

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Citations

Jun 21, 2018·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Lisa FranzénAnders Helander
Jan 2, 2021·Forensic Science International : Synergy·Nicole S Jones, Jeffrey H Comparin
Feb 19, 2021·Forensic Science International : Synergy·Thomas Castaing-CordierJonathan Farjon

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