Abstract
We describe a multicenter descriptive case series of six patients admitted with synthetic cannabinoid (SC) intoxication displaying similar symptoms and sequelae, all resulting in multiple organ failure. Patients were included in this report if they presented with known SC use and experienced multiple organ failure between March 1, 2016, and July 19, 2016, to the intensive care units of three hospitals in Maryland. Patients were followed to either discharge or death, and complications related to SC were documented. All six patients presented with altered mental status and severe rhabdomyolysis, with a peak creatine phosphokinase ranging from 4000 to >320,000 units/L. The majority of patients (five of six) presented with acute kidney injury, with most (four of six) requiring continuous renal replacement therapy. Most patients experienced fever (five of six) and myocardial injury, as evidenced by a troponin elevation (three of six). Seizures occurred in half of patients (three of six patients). Two patients required emergent fasciotomies of the bilateral lower extremities for acute compartment syndrome. Two patients developed fulminant hepatic failure that necessitated liver transplant evaluation, one requiring Molecular Adsorbent...Continue Reading
References
Nov 3, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·A Mallat, S Lotersztajn
Jul 1, 2008·Pharmacology, Biochemistry, and Behavior·Ivana SvízenskáAlexandra Sulcová
Dec 17, 2008·Congestive Heart Failure·Partha MukhopadhyayPál Pacher
Dec 18, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Gautam Kantilal BhanushaliDenyse Thornley-Brown
Mar 23, 2013·Clinical Schizophrenia & Related Psychoses·Dante DurandDiana Nichols-Vinueza
Dec 10, 2013·Forensic Science International : Synergy·Kathryn A SeelyJeffery H Moran
Feb 12, 2014·Workplace Health & Safety·Susan A Randolph
May 31, 2014·Journal of Analytical Toxicology·George BehonickChady Meroueh
Dec 31, 2014·The American Journal of Case Reports·Israr A SheikhJoan A Culpepper-Morgan
Mar 12, 2015·Kidney International·Lola LecruHélène François
Sep 4, 2015·Journal of Community Hospital Internal Medicine Perspectives·Dolkar SherpaRobert Dobbin Chow
Apr 15, 2016·Current Psychiatry Reports·Ziva D Cooper
Jul 2, 2016·Current Opinion in Nephrology and Hypertension·Deanne H Hryciw, Andrew J McAinch
Jul 16, 2016·MMWR. Morbidity and Mortality Weekly Report·Anne M RiedererUNKNOWN Toxicology Investigators Consortium (ToxIC)
Aug 9, 2016·North American Journal of Medical Sciences·Demilade A AdedinsewoTaylor Todd
Dec 25, 2016·Current Topics in Behavioral Neurosciences·Sherrica Tai, William E Fantegrossi
Citations
Jan 11, 2020·Pharmacotherapy·C Lindsay DeVane
Feb 23, 2020·Critical Care Nursing Quarterly·Kent A OwusuJeffrey Mucksavage
Sep 7, 2019·Medicine·Mona N BahouthSatish Shanbhag
Oct 9, 2019·International Journal of Environmental Research and Public Health·Jürgen RehmBundit Sornpaisarn
Dec 20, 2019·Drug Testing and Analysis·Ryan M Alam, John J Keating
Feb 14, 2020·International Journal of Molecular Sciences·Monia LenziMatteo Marti
Apr 7, 2020·Archives of Toxicology·Dino Luethi, Matthias E Liechti
Jan 9, 2021·Therapeutic Advances in Psychopharmacology·Abu ShafiDerek K Tracy
Apr 17, 2021·Journal of Analytical Toxicology·Shiyang QinJianghai Lu