Synthetic cannabinoids in hair - Pragmatic approach for method updates, compound prevalences and concentration ranges in authentic hair samples

Analytica Chimica Acta
Florian FranzMerja A Neukamm

Abstract

Since the first detection of synthetic cannabinoids (SCs) in so-called 'legal high' products (e.g. 'Spice') sold as legal alternatives to marihuana, the rapid development of this class of designer drugs poses a great challenge for analytical laboratories. The aim of this study was the comprehensive validation of an up-to-date LC-MS/MS method for detection of SCs in human hair for the purpose of drug abstinence testing and evaluation of a pragmatic re-validation approach for frequent method adaption. The validation demonstrated low quantification limits (0.5-5.0 pg mg-1) and acceptable selectivity, linearity, accuracy, and precision for 72 SCs. High matrix effects have been taken into consideration as a major limitation of the method. The partial re-validation approach proved to be an appropriate compromise between reduced validation effort and sufficient control of the method performance enabling analysts to keep pace with the dynamics of the drug market. The analysis of 294 authentic samples resulted in 163 positive samples and showed a broad concentration range (<1.0-5,700 pg mg-1) for 52 SCs in hair with up to 17 different compounds detected in a single hair sample. Periods of detection between one and 58 months were observe...Continue Reading

Citations

Jan 4, 2019·Drug Testing and Analysis·Nadia ArboucheAlice Ameline
Jan 29, 2021·Pharmacology, Biochemistry, and Behavior·Savanah L Saldaña-ShumakerChristopher W Cunningham
Mar 26, 2021·International Journal of Legal Medicine·Sophie SalleJean-Michel Gaulier
Apr 17, 2021·Journal of Analytical Toxicology·Shiyang QinJianghai Lu
Sep 4, 2020·Bioorganic & Medicinal Chemistry Letters·Narsimha Reddy PenthalaPeter A Crooks

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