Synthetic cannabinoids: the multi-organ failure and metabolic derangements associated with getting high

Journal of Community Hospital Internal Medicine Perspectives
Dolkar SherpaRobert Dobbin Chow

Abstract

Synthetic cannabinoids (SC), though not detected with routine urine toxicology screening, can cause severe metabolic derangements and widespread deleterious effects in multiple organ systems. The diversity of effects is related to the wide distribution of cannabinoid receptors in multiple organ systems. Both cannabinoid-receptor-mediated and non-receptor-mediated effects can result in severe cardiovascular, renal, and neurologic manifestations. We report the case of a 45-year-old African American male with ST-elevation myocardial infarction, subarachnoid hemorrhage, reversible cardiomyopathy, acute rhabdomyolysis, and severe metabolic derangement associated with the use of K2, an SC. Though each of these complications has been independently associated with SCs, the combination of these effects in a single patient has not been heretofore reported. This case demonstrates the range and severity of complications associated with the recreational use of SCs. Though now banned in the United States, use of systemic cannabinoids is still prevalent, especially among adolescents. Clinicians should be aware of their continued use and the potential for harm. To prevent delay in diagnosis, tests to screen for these substances should be made ...Continue Reading

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Citations

Sep 4, 2015·Journal of Community Hospital Internal Medicine Perspectives·Robert P Ferguson
Feb 23, 2017·Revista da Associação Médica Brasileira·Alper AlpSibel Ersan
Oct 25, 2017·JAAPA : Official Journal of the American Academy of Physician Assistants·Shaina A Freund, Adrian S Banning
Dec 31, 2017·BMC Nephrology·Kanaan MansoorZeid J Khitan
Feb 28, 2019·Pharmacotherapy·Faith ArmstrongMojdeh S Heavner
Dec 12, 2018·Turkish Journal of Emergency Medicine·Aynur SahinSahin Kaplan
Jan 11, 2020·Frontiers in Pharmacology·Sabrina Rahman Archie, Luca Cucullo
Apr 7, 2020·Archives of Toxicology·Dino Luethi, Matthias E Liechti

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