Synthetic DNA-Binding Inhibitor of HES1 Alters the Notch Signaling Pathway and Induces Neuronal Differentiation

ACS Omega
Yulei WeiHiroshi Sugiyama

Abstract

Synthetic DNA-binding inhibitors capable of gaining precise control over neurogenesis factors could obviate the current clinical barriers associated with the use of small molecules in regenerative medicine. Here, we report the design and bioefficacy of the synthetic ligand PIP-RBPJ-1, which caused promoter-specific suppression of neurogenesis-associated HES1 and its downstream genes. Furthermore, PIP-RBPJ-1 alone altered the neural-system-associated Notch-signaling factors and remarkably induced neurogenesis with an efficiency that was comparable to that of a conventional approach.

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Citations

Feb 12, 2019·Advanced Drug Delivery Reviews·Zutao YuHiroshi Sugiyama

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Methods Mentioned

BETA
column chromatography
transfection
immunoprecipitation
ChIP
PCR
Assay
transfect
Immunoprecipitation-PCR

Software Mentioned

Ingenuity Pathway Analysis
Neurite Tracer
image J
QIAGEN

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