PMID: 6403651Mar 1, 1983Paper

Synthetic Fc peptide-mediated regulation of the immune response. I. Characterization of the immunomodulating properties of a synthetic 23-amino acid peptide derived from the sequence of the CH3 domain of human IgG1

The Journal of Experimental Medicine
E L MorganW O Weigle

Abstract

A synthetic 23-amino acid peptide derived from the CH3 domain of human IgG1 was found to be a potent adjuvant as well as a polyclonal activator. The Fc peptide was found to enhance human and murine humoral, and T cell-mediated immune responses. Moreover, in vivo administration of Fc peptide enhanced murine natural killer cell activity. The synthetic Fc peptide was found to be more potent, on a molar basis, than native Fc fragments in inducing polyclonal antibody production and potentiating immune responses.

References

Aug 1, 1979·The Journal of Experimental Medicine·E L Morgan, W O Weigle
Mar 1, 1975·The Journal of Experimental Medicine·G Möller, A Coutinho
Jan 1, 1972·Transplantation Reviews·E Diener, M Feldmann
Aug 1, 1972·European Journal of Immunology·O SjöbergG Möller
Aug 1, 1974·Journal of Immunological Methods·I A Ly, R I Mishell
May 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·G M EdelmanM J Waxdal
Jan 1, 1980·Journal of Supramolecular Structure·E L Morgan, W O Weigle
Jan 1, 1980·The Journal of Experimental Medicine·E L Morgan, W O Weigle

❮ Previous
Next ❯

Citations

Jan 1, 1985·Comparative Immunology, Microbiology and Infectious Diseases·P Lefrancier
Dec 1, 1986·Immunopharmacology·E L MorganM V Hobbs
Feb 12, 2014·Biochemistry. Biokhimii︠a︡·E V Navolotskaya
Dec 1, 1986·Scandinavian Journal of Immunology·U Hammerling, M K Hoffmann
Jan 1, 1992·Immunopharmacology and Immunotoxicology·J KádárP Gergely
Aug 1, 1986·European Journal of Immunology·C N BaxevanisM Papamichail
Nov 1, 1986·Immunological Investigations·E L MorganW O Weigle
Nov 1, 1986·Molecular Immunology·W H FridmanC Neauport-Sautes

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.