Synthetic genomics: a new venture to dissect genome fundamentals and engineer new functions

Current Opinion in Chemical Biology
Daniel SchindlerYizhi Cai

Abstract

Since the first synthetic gene was synthesized in 1970s, the efficiency and the capacity of made-to-order DNA sequence synthesis has increased by several orders of magnitude. Advances in DNA synthesis and assembly over the past years has resulted in a steep drop in price for custom made DNA. Similar effects were observed in DNA sequencing technologies which underpin DNA-reading projects. Today, synthetic DNA sequences with more than 10000bps and turn-around times of a few weeks are commercially available. This enables researchers to perform large-scale projects to write synthetic chromosomes and characterize their functionalities in vivo. Synthetic genomics opens up new paradigms to study the genome fundamentals and engineer novel biological functions.

Citations

Nov 23, 2018·Science China. Life Sciences·Zhouqing LuoJunbiao Dai
Jun 13, 2019·Applied Microbiology and Biotechnology·Hannah PetrekAi-Ming Yu
Oct 5, 2019·Nucleic Acids Research·Miguel Angel MartínezMaria Nevot
Jan 24, 2020·Frontiers in Bioengineering and Biotechnology·Sara Castaño-CerezoGilles Truan
Dec 18, 2020·Molecular Systems Biology·Dominick MatteauSébastien Rodrigue

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Methods Mentioned

BETA
Polymerase Chain Reaction
PCR

Software Mentioned

SCRaMbLE
GP
write
HGP
Genome Project - write
Synthetic Chromosome Rearrangement and Modification by LoxP - ...
GP - write

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