Synthetic genomics: potential and limitations

Current Opinion in Biotechnology
Michael G MontagueSanjay Vashee

Abstract

Technologies to synthetically assemble chromosome sized fragments of DNA as well as to enable making thousands of simultaneous changes to existing genomes are now available. These capacities are collectively termed synthetic genomics. The implications of synthetic genomics extend beyond the limited pathway and gene engineering of the past to include the engineering or whole metabolisms, regulatory networks, and even ecosystems. However, in order for those potentials to be met, certain limitations and barriers must be overcome. These barriers no longer include DNA modification and assembly, but instead are based in the limited organisms that many synthetic genomics methods function in, and the limited software for designing custom genomic sequences.

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Citations

Jun 19, 2014·Nucleic Acids Research·Carole LartigueStephen Douthwaite
Dec 19, 2014·Frontiers in Microbiology·Andrew F Gardner, Zvi Kelman
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Dec 18, 2020·Molecular Systems Biology·Dominick MatteauSébastien Rodrigue

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