PMID: 6407411Jul 1, 1983Paper

Synthetic immunomodulators for prevention of fatal infections in a burned guinea pig model

Annals of Surgery
J D StinnettJ W Alexander

Abstract

Individuals who have suffered severe trauma, such as burns, have a high incidence of infection associated with impaired host resistance. Nonspecific stimulators of host defense mechanisms, i.e., immunomodulators, may be of benefit in such situations. A small animal model (guinea pigs) was developed to study the efficacy of immunomodulators in burns. Anesthetized animals received a 20% total body surface area, full-thickness, scald burn. There was no mortality associated with this injury, but these animals were highly susceptible to challenge with Pseudomonas aeruginosa strain 1244 by direct injection into the burn wound within 24 hours of injury. This susceptibility persisted about 7 days. The standard model adopted was to injure animals, then challenge with 1 median lethal dose (LD50) of P. aeruginosa 96 hours after injury. Using this model, six synthetic immunomodulators were tested: CP-20,961, CP-46,665, muramyl dipeptide, thymopoietin pentapeptide (TP-5), levamisole, and lithium. Drug administration began 24 hours after injury and ended prior to challenge with P. aeruginosa at 96 hours. CP-20,961, muramyl dipeptide, levamisole, and lithium all had no beneficial effect on survival. A single dosage (0.3 mg/kg, I.V.) of CP-46,...Continue Reading

References

Oct 1, 1976·The Journal of Surgical Research·R R Wolfe, H I Miller
Sep 1, 1979·Annals of Surgery·J L MeakinsL D MacLean
Jan 1, 1980·Journal of Immunopharmacology·T Di PerriA Auteri

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Citations

Nov 28, 1985·The New England Journal of Medicine·R H Demling
Apr 28, 2004·American Journal of Clinical Dermatology·Noah ScheinfeldJeffrey M Weinberg
Jan 1, 1984·Journal of Immunopharmacology·E J Wing, S Boehmer
Dec 1, 1984·Journal of Pediatric Surgery·D R CooneyM P Karp
Oct 1, 1993·The British Journal of Surgery·O CetinkaleA Pusane
Jun 12, 2010·Expert Opinion on Therapeutic Targets·Sergey M Lunin, Elena G Novoselova
Jun 28, 2011·Virulence·Tianhong DaiMichael R Hamblin
Jan 1, 1989·Immunopharmacology and Immunotoxicology·H Singh, D N Herndon
Jun 2, 1998·The British Journal of Surgery·M Schäffer, A Barbul
Jun 1, 1984·Infection and Immunity·L D LooseJ Turinsky

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