Synthetic innate defence regulator peptide enhances in vivo immunostimulatory effects of CpG-ODN in newborn piglets

Vaccine
Ding CaoLinghua Zhang

Abstract

The in vivo immunoadjuvant effects of CpG oligodeoxynucleotides (CpG-ODN) have been studied extensively in mice and relatively fewer studies have been done in piglets. But so far, the innate immunostimulatory effects of CpG-ODN combination with innate defense-regulator peptides (IDRs) have not been demonstrated. The purpose of this study is to determine the potential effects of CpG-ODN with IDR in newborn piglets. The immunostimulatory abilities of four selected IDRs were compared, among them HH2 showed best immunostimulatory effects in newborn piglets. Hereafter, the abilities of CpG-ODN combined with HH2 to enhance innate immune responses were examined in newborn piglets. The complex of HH2 and CpG-ODN could induce much stronger Th1 cytokine and chemokine responses than HH2 or CpG-ODN alone. HH2-CpG-ODN immunized piglets showed higher B cell percentage in PBMCs than CpG-ODN alone. These in vivo data demonstrated for the first time that subcutaneously (SC) administration of CpG-ODN combined with HH2 is efficient to stimulate innate immune system in newborn piglets.

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Citations

Oct 4, 2013·Immunotherapy·Cesar Enrique Rivas-SantiagoBruno Rivas-Santiago
Jul 4, 2012·Molecular Immunology·Miaopeng MaLinghua Zhang
Nov 30, 2012·Biopolymers·Annia AlbaAnselmo J Otero-González
Aug 2, 2014·Veterinary Immunology and Immunopathology·Haiming CaiLinghua Zhang
May 7, 2016·Vaccines·Ghania ChikhRisini D Weeratna
Jul 3, 2019·Current Pharmaceutical Design·Adrian Rodríguez-CarlosBruno Rivas-Santiago

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