Synthetic long peptide-based vaccine formulations for induction of cell mediated immunity: A comparative study of cationic liposomes and PLGA nanoparticles

Journal of Controlled Release : Official Journal of the Controlled Release Society
E VarypatakiW Jiskoot

Abstract

Nanoparticulate formulations for synthetic long peptide (SLP)-cancer vaccines as alternative to clinically used Montanide ISA 51- and squalene-based emulsions are investigated in this study. SLPs were loaded into TLR ligand-adjuvanted cationic liposomes and PLGA nanoparticles (NPs) to potentially induce cell-mediated immune responses. The liposomal and PLGA NP formulations were successfully loaded with up to four different compounds and were able to enhance antigen uptake by dendritic cells (DCs) and subsequent activation of T cells in vitro. Subcutaneous vaccination of mice with the different formulations showed that the SLP-loaded cationic liposomes were the most efficient for the induction of functional antigen-T cells in vivo, followed by PLGA NPs which were as potent as or even more than the Montanide and squalene emulsions. Moreover, after transfer of antigen-specific target cells in immunized mice, liposomes induced the highest in vivo killing capacity. These findings, considering also the inadequate safety profile of the currently clinically used adjuvant Montanide ISA-51, make these two particulate, biodegradable delivery systems promising candidates as delivery platforms for SLP-based immunotherapy of cancer.

References

Sep 2, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·T NakanishiT Mayumi
Oct 26, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·W J van DrielJ B Trimbos
Sep 21, 2000·Immunology Letters·F OssendorpC J Melief
Aug 8, 2001·Advanced Drug Delivery Reviews·M A Swartz
Mar 23, 2006·Annual Review of Immunology·Flora Castellino, Ronald N Germain
Mar 28, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yasemin Ataman-OnalBernard Verrier
Jul 11, 2006·Vaccine·Jerome AucouturierLaurent Dupuis
Oct 20, 2006·Trends in Immunology·Sai T ReddyJeffrey A Hubbell
Oct 25, 2006·Molecular Membrane Biology·Dileep P VangasseriLeaf Huang
Apr 26, 2007·Journal of Immunotherapy·Praveen ElamanchiliJohn Samuel
Aug 29, 2007·Cancer Immunology, Immunotherapy : CII·Weihsu ChenLeaf Huang
Jan 4, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Gemma G KenterCornelis J M Melief
Mar 8, 2008·Advanced Drug Delivery Reviews·Laura J PeekCory Berkland
Nov 6, 2009·The New England Journal of Medicine·Gemma G KenterCornelis J M Melief
Sep 9, 2010·Expert Review of Vaccines·Moses O OyewumiZhengrong Cui
May 12, 2011·International Reviews of Immunology·Cheryl Lai-Lai ChiangGeorge Coukos
Jul 21, 2011·Journal of Drug Delivery·Aiala SalvadorJosé Luis Pedraz
Jan 17, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jean-Pierre AmorijWim Jiskoot
May 15, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Medha D JoshiEnrico Mastrobattista
Sep 29, 2012·Nature Reviews. Immunology·Jean-Philippe GirardReinhold Förster
Oct 12, 2012·The AAPS Journal·Vijaya B JoshiAliasger K Salem
Dec 4, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·A L SilvaW Jiskoot
Jun 14, 2013·International Journal of Nanomedicine·Rita Elena Serda
Jul 31, 2013·Immunity·Karolina Palucka, Jacques Banchereau
May 2, 2014·Frontiers in Immunology·Cynthia M FehresYvette van Kooyk
Jun 22, 2014·Cancer Immunology Research·Gijs G ZomFerry Ossendorp

❮ Previous
Next ❯

Citations

May 11, 2016·Expert Review of Vaccines·Gabriela Navarro-TovarSergio Rosales-Mendoza
Jun 6, 2018·Frontiers in Immunology·Rory C F De BritoAlexandre B Reis
Dec 14, 2018·Oncoimmunology·Lucillia BezuLorenzo Galluzzi
Nov 30, 2019·Tissue Barriers·Jacob C McCright, Katharina Maisel
Jul 7, 2018·Seminars in Immunopathology·T TranEric Tartour
Aug 2, 2018·Proceedings of the National Academy of Sciences of the United States of America·Lei DengBao-Zhong Wang
Aug 3, 2019·Acta Pharmacologica Sinica·Ang GaoHai-Jun Yu
Mar 4, 2020·Acta Pharmacologica Sinica·Fan YangZhi-Yong Qian
May 15, 2018·Frontiers in Immunology·Brett J HosFerry Ossendorp
Feb 2, 2017·Cancer Immunology Research·Eleni Maria VarypatakiFerry Ossendorp
Jan 12, 2021·The Journal of Membrane Biology·Daniel E OtzenFarhang Aliakbari
Nov 8, 2020·Pharmaceutics·Zili GuLuis J Cruz
Mar 8, 2020·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Parvin ZamaniMahmoud Reza Jaafari
May 1, 2021·Pharmaceutics·Jeroen HeutsKoen van der Maaden
Jul 3, 2021·Pharmaceutics·Maarten K Nijen TwilhaarJoke M M den Haan
Jul 20, 2021·Frontiers in Immunology·Alexander J StephensShisong Jiang
Jul 16, 2021·Frontiers in Cell and Developmental Biology·Ahmed SalahYuehong Wu
Aug 5, 2020·Advanced Drug Delivery Reviews·Alexander J Najibi, David J Mooney
Sep 10, 2021·International Journal of Pharmaceutics·Zhiling LiuPeng Zhang
Dec 22, 2021·Expert Review of Vaccines·Maryam Abbaspour, Vajihe Akbari

❮ Previous
Next ❯

Related Concepts

Related Feeds

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.