Jun 1, 1976

Synthetic MIF has no effect on beta-MSH and ACTH hypersecretion in Nelson's syndrome

The Journal of Clinical Endocrinology and Metabolism
M DonnadieuM Binoux

Abstract

The effect of synthetic MIF (H-Pro-Leu-Gly-NH2) on beta-MSH secretion was studied in five patients with Nelson's syndrome and in one patient with Addison's disease. Two milligrams of the tripetide were injected intravenously (1 mg in an acute injection, followed by a 30-minute-infusion of 1 mg in 20 ml of saline solution). No consistent effect could be observed during the 90-minute period after the beginning of the infusion. In the same patients, LVP stimulation and dexamethasone suppression tests brought about significant changes in the plasma beta-MSH and ACTH levels.

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Mentioned in this Paper

POMC wt Allele
Organum Vasculosum Laminae Terminalis
Acth Hypersecretion
POMC gene
Recombinant Corticotropin
POMC
Dexamethasone Suppression Test
Melanocyte-Stimulating Hormone, beta
Adrenocorticotropic Hormone Measurement
Pituitary Carcinoma

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