Synthetic molecules as antibody replacements

Accounts of Chemical Research
Thomas KodadekPrasanna G Alluri

Abstract

Antibodies are by far the most versatile, valuable, and widely used protein-binding agents. They are essential tools in biological research and are increasingly being developed as therapeutic reagents. However, antibodies have a number of practical limitations, and it would be desirable in many applications to replace them with simpler, more robust synthetic molecules. Unfortunately, synthetic protein-binding agents rarely exhibit the high affinity and specificity typical of a good antibody. This article reviews efforts to overcome these limitations and to develop a facile, high-throughput methodology for the isolation of synthetic protein ligands with antibody-like binding characteristics.

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Citations

Nov 25, 2011·Analytical Chemistry·Matthew S Luchansky, Ryan C Bailey
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