PMID: 7538326Jan 1, 1994Paper

Synthetic oligoribonucleotides carrying site-specific modifications for RNA structure-function analysis

Biochimie
J A Grasby, M J Gait

Abstract

Synthetic oligoribonucleotides have become increasingly valuable in studies of RNA structure and function. A range of nucleotide analogues is available which carry modifications in the base, sugar or phosphate moieties. Such analogues have been incorporated into synthetic RNA structures to eliminate or alter individual functional groups in the RNA which potentially can take part in hydrogen-bonding or other non-covalent interactions. Comparisons of the properties of the modified RNAs with unmodified RNA models allow conclusions to be drawn concerning the importance or otherwise of specific functional groups within the RNA. These methods have been applied to studies of RNA interactions with proteins, RNA catalysis and RNA structure.

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Citations

Mar 29, 2000·Biopolymers·P J Beuning, K Musier-Forsyth
Mar 9, 2002·Nucleic Acids Research·Sean P Ryder, Scott A Strobel
Jun 1, 1997·Bioorganic & Medicinal Chemistry·Y KomatsuE Ohtsuka
Aug 2, 2008·Archives of Biochemistry and Biophysics·P Patrick DotsonStephen M Testa
Jun 11, 1999·Current Opinion in Structural Biology·S A Strobel
Jun 3, 2009·Current Protocols in Nucleic Acid Chemistry·Barbara Nawrot, Elzbieta Sochacka

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