Synthetic Peptide dendrimers block the development and expression of experimental allergic encephalomyelitis

The Journal of Immunology : Official Journal of the American Association of Immunologists
K WegmannDavid J Hinrichs

Abstract

Multiple Ag peptides (MAPs) containing eight proteolipid protein (PLP)(139-151) peptides arranged around a dendrimeric branched lysine core were used to influence the expression and development of relapsing experimental allergic encephalomyelitis (EAE) in SJL mice. The PLP(139-151) MAPs were very efficient agents in preventing the development of clinical disease when administered after immunization with the PLP(139-151) monomeric encephalitogenic peptide in CFA. The treatment effect with these MAPs was peptide specific; irrelevant multimeric peptides such as guinea pig myelin basic protein GPBP(72-84) MAP (a dendrimeric octamer composed of the 72-84 peptide) and PLP(178-191) MAP (a dendrimeric octamer composed of the PLP(178-191) peptide) had no treatment effect on PLP(139-151)-induced EAE. PLP(139-151) MAP treatment initiated after clinical signs of paralysis also altered the subsequent course of EAE; it limited developing signs of paralysis and effectively limited the severity and number of disease relapses in MAP-treated mice over a 60-day observation period. PLP(139-151) MAP therapy initiated before disease onset acts to limit the numbers of Th17 and IFN-gamma-producing cells that enter into the CNS. However, Foxp3(+) cells...Continue Reading

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Citations

May 8, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·András KolozsiBéla Gyurcsik
Feb 28, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ellen J LeeHolly L Rosenzweig
Jan 18, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jia-Bin SunJan Holmgren
Dec 18, 2009·Endocrinology·Banu S ZolnikMarina A Dobrovolskaia
Mar 9, 2018·Frontiers in Immunology·Takashi Kei Kishimoto, Roberto A Maldonado
Feb 6, 2015·Bioconjugate Chemistry·Lin-Ping WuSeyed Moein Moghimi
Sep 10, 2020·Molecular Pharmaceutics·Matthew A ChristopherCory J Berkland
Jul 18, 2009·Biochimica Et Biophysica Acta·Peizhong Mao, P Hemachandra Reddy
Oct 8, 2021·Angewandte Chemie·Dina ErzinaJean-Louis Reymond

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