The design and generation of molecules capable of mimicking the binding and/or functional sites of proteins represents a promising strategy for the exploration and modulation of protein function through controlled interference with the underlying molecular interactions. Synthetic peptides have proven an excellent type of molecule for the mimicry of protein sites because such peptides can be generated as exact copies of protein fragments, as well as in diverse chemical modifications, which includes the incorporation of a large range of non-proteinogenic amino acids as well as the modification of the peptide backbone. Apart from extending the chemical and structural diversity presented by peptides, such modifications also increase the proteolytic stability of the molecules, enhancing their utility for biological applications. This article reviews recent advances by this and other laboratories in the use of synthetic protein mimics to modulate protein function, as well as to provide building blocks for synthetic biology.
A synthetic peptide inhibitor of human immunodeficiency virus replication: correlation between solution structure and viral inhibition
Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface
Peptides corresponding to a predictive alpha-helical domain of human immunodeficiency virus type 1 gp41 are potent inhibitors of virus infection
Anti-human immunodeficiency virus type 1 human monoclonal antibodies that bind discontinuous epitopes in the viral glycoproteins can identify mimotopes from recombinant phage peptide display libraries
Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody
Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein
Synthesis and study of peptides with semirigid i and i + 7 side-chain bridges designed for alpha-helix stabilization
Rational engineering of a miniprotein that reproduces the core of the CD4 site interacting with HIV-1 envelope glycoprotein
Effect of D-amino acid substitution on the stability, the secondary structure, and the activity of membrane-active peptide
Chemically prepared hevein domains: effect of C-terminal truncation and the mutagenesis of aromatic residues on the affinity for chitin
Polar interactions with aromatic side chains in alpha-helical peptides: Ch...O H-bonding and cation-pi interactions
Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides
The SPOT-synthesis technique. Synthetic peptide arrays on membrane supports--principles and applications
Simple cation-pi interaction between a phenyl ring and a protonated amine stabilizes an alpha-helix in water
Rational design of a CD4 mimic that inhibits HIV-1 entry and exposes cryptic neutralization epitopes
Helix-stabilized cyclic peptides as selective inhibitors of steroid receptor-coactivator interactions
Thermally reversible hydrogels via intramolecular folding and consequent self-assembly of a de novo designed peptide
Synthesis and helical structure of lactam bridged BH3 peptides derived from pro-apoptotic Bcl-2 family proteins
Chemotaxis inhibitory protein of Staphylococcus aureus binds specifically to the C5a and formylated peptide receptor
'100 years of peptide synthesis': ligation methods for peptide and protein synthesis with applications to beta-peptide assemblies
Properties and structure-activity studies of cyclic beta-hairpin peptidomimetics based on the cationic antimicrobial peptide protegrin I
Rapid and quantitative cyclization of multiple peptide loops onto synthetic scaffolds for structural mimicry of protein surfaces
Covalent stabilization of coiled coils of the HIV gp41 N region yields extremely potent and broad inhibitors of viral infection
The structure of the C5a receptor-blocking domain of chemotaxis inhibitory protein of Staphylococcus aureus is related to a group of immune evasive molecules
Light-activated hydrogel formation via the triggered folding and self-assembly of a designed peptide
The world of beta- and gamma-peptides comprised of homologated proteinogenic amino acids and other components
Nonstereogenic alpha-aminoisobutyryl-glycyl dipeptidyl unit nucleates type I' beta-turn in linear peptides in aqueous solution
Post-translational modifications and regulation of the RAS superfamily of GTPases as anticancer targets
An urokinase receptor antagonist that inhibits cell migration by blocking the formyl peptide receptor
Synthesis of protein mimics with nonlinear backbone topology by a combined recombinant, enzymatic, and chemical synthesis strategy
Structure of the tyrosine-sulfated C5a receptor N terminus in complex with chemotaxis inhibitory protein of Staphylococcus aureus
Identification of conformational epitopes for human IgG on Chemotaxis inhibitory protein of Staphylococcus aureus
A general approach for the non-stop solid phase synthesis of TAC-scaffolded loops towards protein mimics containing discontinuous epitopes
Tuning the pH responsiveness of beta-hairpin peptide folding, self-assembly, and hydrogel material formation
Structure-based design of an urokinase-type plasminogen activator receptor-derived peptide inhibiting cell migration and lung metastasis
A combinatorial approach for the design of complementarity-determining region-derived peptidomimetics with in vitro anti-tumoral activity
Remodeling of dynamic structures of HIV-1 envelope proteins leads to synthetic antigen molecules inducing neutralizing antibodies
Vaccination with peptide mimetics of the gp41 prehairpin fusion intermediate yields neutralizing antisera against HIV-1 isolates
A peptide mimic of the chemotaxis inhibitory protein of Staphylococcus aureus: towards the development of novel anti-inflammatory compounds.
NMR structure of the first extracellular domain of corticotropin-releasing factor receptor 1 (ECD1-CRF-R1) complexed with a high affinity agonist.
Binding of CDR-derived peptides is mechanistically different from that of high-affinity parental antibodies
Synthesis of cell-permeable stapled peptide dual inhibitors of the p53-Mdm2/Mdmx interactions via photoinduced cycloaddition
Mapping backbone and side-chain interactions in the transition state of a coupled protein folding and binding reaction
Synthesis of a trimeric gp120 epitope mimic conjugated to a T-helper peptide to improve antigenicity
Biochemistry and biophysics of HIV-1 gp41 - membrane interactions and implications for HIV-1 envelope protein mediated viral-cell fusion and fusion inhibitor design
Design of triazole-stapled BCL9 α-helical peptides to target the β-catenin/B-cell CLL/lymphoma 9 (BCL9) protein-protein interaction
Broadly neutralizing antibodies present new prospects to counter highly antigenically diverse viruses
Cell-permeable stapled peptides based on HIV-1 integrase inhibitors derived from HIV-1 gene products
Stapled α-helical peptide drug development: a potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy
The cyclic cystine ladder of theta-defensins as a stable, bifunctional scaffold: A proof-of-concept study using the integrin-binding RGD motif
Enhancement and induction of HIV-1 infection through an assembled peptide derived from the CD4 binding site of gp120
Structure-activity relationship study of novel peptoids that mimic the structure of antimicrobial peptides
Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes.
Immunogenicity of a Fap2 peptide mimotope ofFusobacterium nucleatum and its potential use in the diagnosis of colorectal cancer
High-throughput Docking and Molecular Dynamics Simulations towards the Identification of Novel Peptidomimetic Inhibitors against CDC7
Large-scale docking predicts that sORF-encoded peptides may function through protein-peptide interactions in Arabidopsis thaliana
Characterizing the binding of dopamine D1-D2 receptors in vitro and in temporal and frontal lobe tissue total protein
A Tunable Nanoplatform of Nanogold Functionalised with Angiogenin Peptides for Anti-Angiogenic Therapy of Brain Tumours
A synthetic peptide analog of in silico-predicted immunogenic epitope unique to dengue virus serotype 2 NS1 antigen specifically binds immunoglobulin G antibodies raised in rabbits
Multifunctional Scaffolds for Assembling Cancer-Targeting Immune Stimulators Using Chemoselective Ligations
Ranacyclin-NF, a Novel Bowman-Birk Type Protease Inhibitor from the Skin Secretion of the East Asian Frog, Pelophylax nigromaculatus
Potent activity of bioconjugated peptide and selenium nanoparticles against colorectal adenocarcinoma cells
Recent Advances in the Design and Sensing Applications of Hemin/Coordination Polymer-Based Nanocomposites
Peptides and pseudopeptide ligands: a powerful toolbox for the affinity purification of current and next-generation biotherapeutics
Meta-Analysis for Correlating Structure of Bioactive Peptides in Foods of Animal Origin with Regard to Effect and Stability
Design and Synthesis of HCV-E2 Glycoprotein Epitope Mimics in Molecular Construction of Potential Synthetic Vaccines.
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