Synthetic Peptides as Protein Mimics

Frontiers in Bioengineering and Biotechnology
Andrea GroßJutta Eichler

Abstract

The design and generation of molecules capable of mimicking the binding and/or functional sites of proteins represents a promising strategy for the exploration and modulation of protein function through controlled interference with the underlying molecular interactions. Synthetic peptides have proven an excellent type of molecule for the mimicry of protein sites because such peptides can be generated as exact copies of protein fragments, as well as in diverse chemical modifications, which includes the incorporation of a large range of non-proteinogenic amino acids as well as the modification of the peptide backbone. Apart from extending the chemical and structural diversity presented by peptides, such modifications also increase the proteolytic stability of the molecules, enhancing their utility for biological applications. This article reviews recent advances by this and other laboratories in the use of synthetic protein mimics to modulate protein function, as well as to provide building blocks for synthetic biology.

References

Oct 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·R J SimonC K Marlowe
Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·C WildT Matthews
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·C T WildT J Matthews
Nov 14, 1997·Proceedings of the National Academy of Sciences of the United States of America·K TanM Lu
Jul 17, 1998·Annals of Medicine·P J DennesenR A Weinstein
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·S F LichtenthalerK Beyreuther
Oct 3, 1999·Journal of Medicinal Chemistry·R A HoughtenJ M Ostresh
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·C VitaJ C Gluckman
Dec 11, 1999·Nucleic Acids Research·H M BermanP E Bourne
Sep 19, 2000·Infection and Immunity·K E VeldkampK P van Kessel
Mar 17, 2001·Nature Reviews. Molecular Cell Biology·Y Yarden, M X Sliwkowski
Jun 28, 2001·Journal of the American Chemical Society·C A OlsonN R Kallenbach
Nov 17, 2001·Chemical Reviews·R P ChengW F DeGrado
Mar 28, 2002·Journal of the American Chemical Society·Zhengshuang ShiNeville R Kallenbach
Nov 6, 2002·Proceedings of the National Academy of Sciences of the United States of America·Samuel K SiaPeter S Kim
Dec 12, 2002·Journal of the American Chemical Society·Lun K TsouMarcey L Waters
Jan 23, 2003·Journal of the American Chemical Society·Ryan A MehlPeter G Schultz
Mar 15, 2003·The New England Journal of Medicine·Jacob P LalezariUNKNOWN TORO 1 Study Group
May 30, 2003·The New England Journal of Medicine·J Michael Kilby, Joseph J Eron
Aug 9, 2003·Journal of the American Chemical Society·Heike FlieglReinhart Ahlrichs
Sep 3, 2003·European Journal of Biochemistry·Tamás A Martinek, Ferenc Fülöp
Sep 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Anne-Marie LeducArno F Spatola
Sep 25, 2003·Journal of the American Chemical Society·Darrin J PochanLisa Haines
Mar 10, 2004·Bioorganic & Medicinal Chemistry Letters·Bin YangZiwei Huang
May 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bent PostmaKok P M van Kessel
Aug 3, 2004·Nature Medicine·Bert Vogelstein, Kenneth W Kinzler
Feb 12, 2005·The Journal of Peptide Research : Official Journal of the American Peptide Society·T Kimmerlin, D Seebach
Apr 7, 2005·Chembiochem : a European Journal of Chemical Biology·Peter TimmermanRob H Meloen
Jun 22, 2005·Accounts of Chemical Research·G Andrew Woolley
Sep 1, 2005·Proceedings of the National Academy of Sciences of the United States of America·Elisabetta BianchiAntonello Pessi
Dec 1, 2005·Journal of the American Chemical Society·Lisa A HainesJoel P Schneider
Mar 16, 2006·Journal of the American Chemical Society·Nicholas L MillsR Kiplin Guy
Apr 28, 2006·Chembiochem : a European Journal of Chemical Biology·Christian Renner, Luis Moroder

❮ Previous
Next ❯

Citations

Nov 2, 2016·ACS Chemical Biology·Yana K RennieAndrew G Jamieson
Jan 27, 2017·Chembiochem : a European Journal of Chemical Biology·Christina HaußnerJutta Eichler
Apr 5, 2019·Organic & Biomolecular Chemistry·I L BatalhaA C A Roque
Oct 31, 2018·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Hiroshi Inaba, Kazunori Matsuura
Apr 6, 2019·Protein and Peptide Letters·Deborah L HeylHedeel Guy Evans
Mar 22, 2019·Frontiers in Chemistry·Anne C ConibearChristian F W Becker
Oct 31, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Johan JooEun Ji Chung
Jun 20, 2019·Journal of Peptide Science : an Official Publication of the European Peptide Society·Steven VerlindenSteven Ballet
Jun 27, 2019·Drug Development and Industrial Pharmacy·V R RanjithaV Ravishankar Rai
Jan 1, 2019·Comprehensive Reviews in Food Science and Food Safety·Elena MaestriNelson Marmiroli
Dec 20, 2020·Biomolecules·Hunain AliFarzana Shaheen
Feb 25, 2021·Chemical Science·Aurora DiamanteLaura S Itzhaki
Oct 17, 2020·Neural Regeneration Research·Ana Paula de A BoletiLudovico Migliolo
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wei WangDian Su
Aug 23, 2018·Biomacromolecules·Biplab SarkarVivek A Kumar
Aug 15, 2018·ACS Synthetic Biology·Benjamin J Des SoyeMichael C Jewett
Jan 6, 2018·ACS Biomaterials Science & Engineering·Christopher PoonEun Ji Chung
Dec 4, 2020·The Journal of Physical Chemistry. B·Chandan Kumar Choudhury, Olga Kuksenok
Oct 27, 2018·Journal of the American Chemical Society·Zhonghan LiMin Xue
Sep 10, 2021·The Journal of Organic Chemistry·Alexis D RichaudStéphane P Roche

❮ Previous
Next ❯

Methods Mentioned

BETA
phage display
protein folding
X-ray
NMR
phage
in silico methods
CLIPS
GTPases
nucleotide exchange
x-ray crystallography

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.