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Synthetic polypeptide antagonists of the hypothalamic luteinizing hormone releasing factor

Science

May 26, 1972

Wylie W ValeRoger Guillemin

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Abstract

Two analogs of the hypothalamic luteinizing hormone releasing factor modified at the histidine-2 position were tested for biological activity (secretion of luteinizing hormone) in cultures of dispersed rat anterior pituitary cells. The analog in which glycine was substituted for histidi...read more

Mentioned in this Paper

Cell Secretion
Analogs & derivatives
Serum LH Measurement
Cells, Cultured [Chemical/Ingredient]
Analog
Recombinant Luteinizing Hormone
Receptors, Drug
Luteozyman
Metazoa
Structure-Activity Relationship
6
1
Paper Details
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Synthetic polypeptide antagonists of the hypothalamic luteinizing hormone releasing factor

Science

May 26, 1972

Wylie W ValeRoger Guillemin

PMID: 4555980

DOI: 10.1126/science.176.4037.933

Abstract

Two analogs of the hypothalamic luteinizing hormone releasing factor modified at the histidine-2 position were tested for biological activity (secretion of luteinizing hormone) in cultures of dispersed rat anterior pituitary cells. The analog in which glycine was substituted for histidi...read more

Mentioned in this Paper

Cell Secretion
Analogs & derivatives
Serum LH Measurement
Cells, Cultured [Chemical/Ingredient]
Analog
6
1

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  • Citations51
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