Synthetic porcine lactoferricin with a 20-residue peptide exhibits antimicrobial activity against Escherichia coli, Staphylococcus aureus, and Candida albicans

Journal of Agricultural and Food Chemistry
Hsiao-Ling ChenChuan-Mu Chen

Abstract

Lactoferricins are positively charged, highly basic peptides that are generated upon gastric pepsin cleavage of various lactoferrins. In the past decade, there has been active investigation of the key antimicrobial segments of the various shorter synthetic bovine and human lactoferricins, but not in porcine lactoferricin. These studies have demonstrated the distinct solution structures of lactoferricin in bovine and human and established the multifunctional nature of the antibacterial, antifungal, antiendotoxin, and antiviral activities of lactoferricins. However, the protective effects of porcine lactoferricins have yet to be elucidated. In the present study, a series of synthetic derivatives of porcine, bovine, and human lactoferricins with 20-residue and 9-residue peptides were prepared to investigate their antimicrobial nature. We found that the 20-residue porcine lactoferricin (LFcin P-20) displayed antimicrobial activity against Escherichia coli ATCC25922, Staphylococcus aureus ATCC25923, and Candida albicans ATCC14053. The minimal inhibitory concentrations and minimal bactericidal concentrations of LFcin P-20 ranged from 12 to 25 microM when tested in bacteria and fungi. LFcin P-20 was 4 times more effective than human l...Continue Reading

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Citations

Mar 4, 2008·Journal of Veterinary Internal Medicine·A LindeT Melgarejo
Jun 1, 2014·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Sarahí Luna-CastroMireya de la Garza
Feb 12, 2010·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Hsiao-Ling ChenChuan-Mu Chen
Mar 3, 2010·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Héctor Flores-VillaseñorJan G M Bolscher
Mar 20, 2010·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Che-Ming HungChuan-Mu Chen
Feb 18, 2011·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Chih-Ching YenChuan-Mu Chen
Feb 6, 2013·Cellular and Molecular Life Sciences : CMLS·Nicole L van der WeerdenMarilyn A Anderson
Oct 12, 2010·Veterinary Immunology and Immunopathology·Sarah ScapinelloJeff L Caswell
Aug 19, 2008·International Journal of Food Microbiology·María EnriquePaloma Manzanares
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May 31, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Yung An TsouCalvin Yu-Chian Chen
Jan 23, 2016·FEBS Open Bio·Ramar Perumal SamyGautam Sethi

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