PMID: 5909695Mar 1, 1966

Synthetic progestagen-oestrogen preparations and endometrial morphology

Journal of Clinical Pathology


19-nor steroids in high and medium dosage in continuous or cyclic combined regimens with oestrogen produce an endometrium characterized by hyperinvoluted glands, a prominent predecidual reaction, suppressed arterioles, and dilated venules. When daily dosage is decreased to 2.0 mg. or less, the endometrium is composed of hyperinvoluted glands in an inert stroma; predecidual reactions are weak and infrequent; venules are rarely dilated, but spiral arterioles are suppressed.17-alpha-Acetoxyprogesterone derivatives in high and medium dosage given in a cyclic combined regimen with oestrogen produce similar but less intense effects to the 19-nor steroids. When given in cyclic sequential regimen, they produce an early secretory endometrium closely resembling normal patterns, chronologically retarded by about five days; in some instances a regressing, undatable secretory pattern is found, but predecidual response is minimal, and dilated venules are not seen.19-nor steroids in medium dosage given for 20 days without added oestrogen produce a late secretory endometrium with unpredictable variation from patient to patient and even from site to site within the same endometrium. Inhibition of the development of spiral arterioles is a common...Continue Reading


Jan 1, 1961·Acta Obstetricia Et Gynecologica Scandinavica·M CRONQVIST, S KULLANDER
Feb 15, 1963·American Journal of Obstetrics and Gynecology·M MAQUEOH RUDEL
Oct 15, 1963·American Journal of Obstetrics and Gynecology·E RICE-WRAYJ W GOLDZIEHER
Nov 15, 1964·American Journal of Obstetrics and Gynecology·G M RYAND E REID
Jan 1, 1965·Archiv für die gesamte Virusforschung·D MORLEY

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