Synthetic repurposing of drugs against hypertension: a datamining method based on association rules and a novel discrete algorithm

BMC Bioinformatics
Yosef Masoudi-Sobhanzadeh, Ali Masoudi-Nejad

Abstract

Drug repurposing aims to detect the new therapeutic benefits of the existing drugs and reduce the spent time and cost of the drug development projects. The synthetic repurposing of drugs may prove to be more useful than the single repurposing in terms of reducing toxicity and enhancing efficacy. However, the researchers have not given it serious consideration. To address the issue, a novel datamining method is introduced and applied to repositioning of drugs for hypertension (HT) which is a serious medical condition and needs some improved treatment plans to help treat it. A novel two-step data mining method, which is based on the If-Then association rules as well as a novel discrete optimization algorithm, was introduced and applied to the synthetic repurposing of drugs for HT. The required data were also extracted from DrugBank, KEGG, and DrugR+ databases. The findings indicated that based on the different statistical criteria, the proposed method outperformed the other state-of-the-art approaches. In contrast to the previously proposed methods which had failed to discover a list on some datasets, our method could find a combination list for all of them. Since the proposed synthetic method uses medications in small dosages, i...Continue Reading

References

Dec 11, 1999·Nucleic Acids Research·M Kanehisa, S Goto
Dec 1, 2007·Nucleic Acids Research·David S WishartMurtaza Hassanali
Jan 21, 2015·Journal of Chemical Information and Modeling·Hiroaki IwataYoshihiro Yamanishi
Mar 31, 2015·PLoS Computational Biology·Deborah A Weighill, Daniel A Jacobson
Oct 1, 2015·Briefings in Bioinformatics·Graciela H GonzalezCasey S Greene
Jun 1, 2016·Drug Discovery Today·Wei SunWei Zheng
Oct 4, 2016·Drug Discovery Today·Quentin VanhaelenAlex Zhavoronkov
Dec 17, 2016·Progress in Cardiovascular Diseases·William H Frishman
Jan 20, 2017·The Lancet Infectious Diseases·Martin J BoereeUNKNOWN PanACEA consortium
Feb 22, 2017·The American Journal of Gastroenterology·Konstantinos Papamichael, Adam S Cheifetz
Nov 11, 2017·Nucleic Acids Research·David S WishartMichael Wilson
Nov 14, 2017·Drug Discovery Today·Robert E PogueFabrício F Costa
Jan 11, 2018·Nature Communications·Dakota E McCoyRichard O Prum
Mar 3, 2018·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Richard J JohnsonGlenn M Chertow
Apr 20, 2018·BMC Bioinformatics·Jiajie PengXuequn Shang
Aug 27, 2018·Current Hypertension Reports·Jared Davis, Suzanne Oparil
Oct 3, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Tomáš SeemanMark Mitsnefes
Oct 13, 2018·Nature Reviews. Drug Discovery·Sudeep PushpakomMunir Pirmohamed
Nov 13, 2018·Artificial Intelligence in Medicine·Sfar HelaRaddaoui Badran
Nov 19, 2018·Neurotoxicology·Fernanda García-AlvaradoAntonio G García
Dec 14, 2018·Methods in Molecular Biology·Ali EzzatChee-Keong Kwoh
Jan 25, 2019·Current Protein & Peptide Science·Qi ZhaoXing Chen
Feb 5, 2019·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Annabella Braschi
Apr 2, 2019·Scientific Reports·Farzad KhalvatiMasoom A Haider
Apr 5, 2019·BMC Bioinformatics·Yosef Masoudi-SobhanzadehAli Masoudi-Nejad
Apr 13, 2019·Nature Reviews. Drug Discovery·Jessica VamathevanShanrong Zhao
Apr 20, 2019·Nature Materials·Sean EkinsAlex M Clark
May 17, 2019·Computers in Biology and Medicine·Yosef Masoudi-SobhanzadehAli Masoudi-Nejad
Jun 13, 2019·BMC Bioinformatics·Mohammed AlQuraishi
Jun 22, 2019·Genomics·Yosef Masoudi-SobhanzadehAli Masoudi-Nejad
Jun 30, 2019·Scientific Reports·Yosef Masoudi-SobhanzadehAli Masoudi-Nejad
Oct 28, 2019·Pharmacological Reports : PR·Begoña Quintana-VillamandosEmilio Delgado-Baeza
Oct 28, 2019·PLoS Computational Biology·Nicholas FranzeseAnna Ritz
Oct 31, 2019·Journal of Chemical Information and Modeling·Karim AbbasiAli Masoudi-Nejad
Nov 14, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Bhim Bahadur RaiTed Maddess
Feb 1, 2020·Pharmacological Reports : PR·Begoña Quintana-VillamandosEmilio Delgado-Baeza
Feb 25, 2020·Genomics·Mahsa Torkamanian-AfsharAli Masoudi-Nejad
Jan 1, 2016·Informatics in Medicine Unlocked·Yosef Masoudi-Sobhanzadeh, Habib Motieghader

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