Synthetic strategies in construction of organic macromolecular carrier-drug conjugates

Organic & Biomolecular Chemistry
Andrzej S SkwareckiMaria J Milewska

Abstract

Many metabolic inhibitors, considered potential antimicrobial or anticancer drug candidates, exhibit very limited ability to cross the biological membranes of target cells. The restricted cellular penetration of those molecules is often due to their highhydrophilicity. One of the possible solutions to this problem is a conjugation of an inhibitor with a molecular organic nanocarrier. The conjugate thus formed should be able to penetrate the membrane(s) by direct translocation, endocytosis or active transport mechanisms and once internalized, the active component could reach its intracellular target, either after release from the conjugate or in an intact form. Several such nanocarriers have been proposed so far, including macromolecular systems, carbon nanotubes and dendrimers. Herein, we present a comprehensive review of the current status of rational design and synthesis of macromolecular organic nanocarrier-drug conjugates, with special attention focused on the mode of coupling of a nanocarrier moiety with a "cargo" molecule through linking fragments of non-cleavable or cleavable type.

References

Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D PapahadjopoulosC Redemann
Jul 26, 1996·Science·A ThessR E Smalley
Aug 16, 1996·Science·I A AksayS M Gruner
Oct 2, 1998·Science·J ChenR C Haddon
Mar 8, 2000·International Journal of Pharmaceutics·O M MilhemA D'Emanuele
Jul 18, 2001·Journal of the American Chemical Society·R J ChenH Dai
Jan 31, 2002·Journal of the American Chemical Society·Vasilios GeorgakilasAndreas Hirsch
Feb 16, 2002·The Journal of Organic Chemistry·Claudia M Cardona, Robert E Gawley
May 16, 2002·Bioconjugate Chemistry·Omayra L Padilla De JesúsFrancis C Szoka
Jan 23, 2003·Chemical Communications : Chem Comm·Vasilios GeorgakilasMaurizio Prato
Jan 30, 2003·Journal of the American Chemical Society·Christopher A Dyke, James M Tour
Feb 15, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ruedeekorn WiwattanapatapeeKrisanee Saramunee
Jun 6, 2003·International Journal of Pharmaceutics·Parag KolheMary Lieh-Lai
Jul 10, 2003·Journal of the American Chemical Society·Michael HolzingerAndreas Hirsch
Jul 17, 2003·Journal of the American Chemical Society·Karl S ColemanMalcolm L H Green
Jul 19, 2003·The Journal of Organic Chemistry·Valérie MaravalJean-Pierre Majoral
Jul 26, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Abhay S ChauhanPrakash V Diwan
Sep 25, 2003·Journal of Nanoscience and Nanotechnology·Marc in het PanhuisAndrew I Minett
Dec 4, 2003·Journal of the American Chemical Society·Hui HuRobert C Haddon
Dec 10, 2003·Journal of Biomaterials Science. Polymer Edition·Hu Yang, Stephanie T Lopina
Jan 23, 2004·Chemical Communications : Chem Comm·Davide PantarottoAlberto Bianco
Mar 17, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Antony D'EmanueleDavid Attwood
Jun 4, 2004·Journal of the American Chemical Society·Nadine Wong Shi KamHongjie Dai
Sep 30, 2004·International Journal of Pharmaceutics·Bharathi DevarakondaMelgardt M de Villiers
Jan 6, 2005·Journal of the American Chemical Society·Alberto BiancoCharalambos D Partidos
Jan 18, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Th F Vandamme, L Brobeck
Jan 27, 2005·Chemical Communications : Chem Comm·Alberto BiancoMaurizio Prato
Mar 17, 2005·Bioconjugate Chemistry·Jayant KhandareRangaramanujam M Kannan
Mar 24, 2005·Journal of the American Chemical Society·Kyung Min LeeLiming Dai
Apr 26, 2005·International Journal of Pharmaceutics·D BhadraN K Jain
Jul 20, 2005·Molecular Pharmaceutics·Michael F NeermanEric E Simanek
Oct 4, 2005·International Journal of Pharmaceutics·Bharathi DevarakondaMelgardt M de Villiers
Oct 18, 2005·European Journal of Medicinal Chemistry·Cheng Yiyun, Xu Tongwen
Oct 20, 2005·Journal of Bioscience and Bioengineering·Zhixiong WangKiyohito Yagi
Oct 20, 2005·Current Opinion in Chemical Biology·Alberto BiancoMaurizio Prato
Nov 22, 2005·Expert Opinion on Drug Delivery·Alberto Bianco
Nov 29, 2005·Advanced Drug Delivery Reviews·Antony D'Emanuele, David Attwood
Dec 8, 2005·Nature Biotechnology·Cameron C LeeFrancis C Szoka
Mar 16, 2006·Bioconjugate Chemistry·Sezen GurdagRangaramanujam M Kannan

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Methods Mentioned

BETA
transmission electron microscopy
amidation
X-ray
transfection
acylation

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