Synthetic studies on the bioactive tetramic acid JBIR-22 using a late stage Diels-Alder reaction

Organic & Biomolecular Chemistry
A R Healy, N J Westwood

Abstract

A late stage Diels-Alder reaction is used to prepare a mixture of JBIR-22, a natural product from the Equisetin family of tetramic acids, and one of its diastereomers. This is achieved in just 8 steps from pyruvate. The success of the late stage DA approach is discussed in the context of the biosynthesis of JBIR-22 (and perhaps related natural products).

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Citations

Mar 21, 2017·Bioinorganic Chemistry and Applications·Dimitrios MatiadisJohn M Markopoulos

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