Synthetic tactile perception induced by transcranial alternating-current stimulation can substitute for natural sensory stimulus in behaving rabbits

Scientific Reports
Javier Márquez-RuizJosé M Delgado-García

Abstract

The use of brain-derived signals for controlling external devices has long attracted the attention from neuroscientists and engineers during last decades. Although much effort has been dedicated to establishing effective brain-to-computer communication, computer-to-brain communication feedback for "closing the loop" is now becoming a major research theme. While intracortical microstimulation of the sensory cortex has already been successfully used for this purpose, its future application in humans partly relies on the use of non-invasive brain stimulation technologies. In the present study, we explore the potential use of transcranial alternating-current stimulation (tACS) for synthetic tactile perception in alert behaving animals. More specifically, we determined the effects of tACS on sensory local field potentials (LFPs) and motor output and tested its capability for inducing tactile perception using classical eyeblink conditioning in the behaving animal. We demonstrated that tACS of the primary somatosensory cortex vibrissa area could indeed substitute natural stimuli during training in the associative learning paradigm.

References

May 11, 1985·Lancet·A T BarkerI L Freeston
Jan 8, 1986·The Journal of Comparative Neurology·H J Gould
Jun 1, 1994·Electroencephalography and Clinical Neurophysiology·J R Wolpaw, D J McFarland
Feb 11, 2000·Journal of Neurophysiology·A GruartJ M Delgado-García
Jun 6, 2002·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jonathan R WolpawTheresa M Vaughan
Apr 17, 2003·Experimental Brain Research·Andrea AntalWalter Paulus
Feb 24, 2004·The Journal of Physiology·Marom BiksonJohn G R Jefferys
Jul 7, 2005·Experimental Brain Research·Felipe FregniAlvaro Pascual-Leone
Jan 27, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Agnès GruartJosé M Delgado-García
Jun 10, 2006·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Pedro Cavaleiro MirandaMark Hallett
Jun 20, 2006·Proceedings of the National Academy of Sciences of the United States of America·Rocio Leal-CampanarioAgnès Gruart
Jul 25, 2006·Trends in Neurosciences·Mikhail A Lebedev, Miguel A L Nicolelis
Aug 26, 2006·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Anne DieckhöferRené Gobbelé
Nov 7, 2006·Nature·Lisa MarshallJan Born
Jan 26, 2007·Journal of Neurophysiology·M A NitscheW Paulus
Jun 30, 2007·The Journal of Physiology·Jacqueline K DeansJohn G R Jefferys
Oct 7, 2008·Lancet Neurology·Janis J Daly, Jonathan R Wolpaw
Nov 26, 2008·Current Biology : CB·Ryota KanaiWalter Paulus
Apr 13, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Ryota KanaiVincent Walsh
Jul 1, 2008·Brain Stimulation·Michael A NitscheAlvaro Pascual-Leone
Aug 27, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Simal OzenGyörgy Buzsáki
Oct 22, 2010·The Journal of Physiology·Vera MoliadzeWalter Paulus
Mar 9, 2011·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Subramaniam Venkatraman, Jose M Carmena
Jun 30, 2011·Frontiers in Psychology·Matteo FeurraRyota Kanai
Aug 9, 2011·Neuropsychological Rehabilitation·Walter Paulus
Aug 26, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Matteo FeurraSimone Rossi
Dec 31, 2011·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Joseph E O'DohertyMiguel A L Nicolelis
Apr 12, 2012·Proceedings of the National Academy of Sciences of the United States of America·Javier Márquez-RuizJosé María Delgado-García
Aug 11, 2012·Science·Antal BerényiGyörgy Buzsáki
Sep 6, 2012·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Giulio RuffiniPedro C Miranda
Dec 21, 2012·Lancet·Grégoire CourtineJosé del R Millán
Jan 1, 2013·NeuroImage·Pedro Cavaleiro MirandaGiulio Ruffini
Feb 14, 2013·Nature Communications·Eric E ThomsonMiguel A L Nicolelis
Mar 2, 2013·Scientific Reports·Miguel Pais-VieiraMiguel A L Nicolelis

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Citations

Jul 18, 2018·Current Behavioral Neuroscience Reports·Carlos A Sánchez-LeónJavier Márquez-Ruiz
Mar 3, 2020·Frontiers in Aging Neuroscience·Shane FresnozaAnja Ischebeck
May 6, 2020·Experimental Brain Research·Marta CastellanoGiulio Ruffini
Feb 6, 2021·Scientific Reports·Carlos A Sánchez-LeónJavier Márquez-Ruiz
Oct 3, 2018·Current Opinion in Biomedical Engineering·Carlos A Sánchez-LeónJavier Márquez-Ruiz

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