PMID: 20632932Jul 17, 2010Paper

Synthetic water-soluble phenolic antioxidant regulates l-arginine metabolism in macrophages: a possible role of Nrf2/ARE

Biochemistry. Biokhimii︠a︡
V O TkachevN N Volsky

Abstract

Synthetic water-soluble phenolic antioxidant TS-13 exhibits pronounced anti-inflammatory properties in vivo and induces intracellular signal system Nrf2/ARE. At concentrations 150-1000 microM it inhibits nitric oxide (NO) production in mouse peritoneal macrophages. However, this compound at low concentrations (1-100 microM) paradoxically increases NO production and decreases activity of arginase. These results are indicative of an ambiguous role of NO and its metabolites in the mechanism of development of inflammatory reaction.

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Citations

May 19, 2011·Biochemistry. Biokhimii︠a︡·V O TkachevN K Zenkov
Feb 6, 2013·Biochemistry. Biokhimii︠a︡·N K ZenkovV O Tkachev
Jun 4, 2014·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Elena MenshchikovaNikolay Zenkov
Feb 25, 2015·Bulletin of Experimental Biology and Medicine·V A BlikN E Chepurnova
Dec 22, 2011·Advances in Gerontology = Uspekhi Gerontologii·O N KirillovskikhT A Borovkova

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