PMID: 11933054Apr 5, 2002Paper

Synucleins in glaucoma: implication of gamma-synuclein in glaucomatous alterations in the optic nerve

Journal of Neuroscience Research
I SurguchevaAndrei Surguchov

Abstract

Synucleins are small proteins associated with neurodegenerative diseases and some forms of cancer. They are studied predominantly in the brain; information about their presence and functions in ocular tissues is scarce. Here we describe the localization of three members of the synuclein family in the optic nerve of donors with different types of glaucoma compared with control samples from donors without ocular diseases. We did not find significant differences in the localization of alpha- and beta-synucleins in the optic nerve or retina of glaucoma patients compared with controls, whereas considerable redistribution of gamma-synuclein occurred in the glaucomatous optic nerve compared with control eye without glaucoma. In the optic nerve from control and glaucomatous individuals, nerve bundles are immunopositive for gamma-synuclein; however, a strong gamma-synuclein-immunopositive staining in a subset of glial cells was observed in the lamina and postlamina cribrosa regions of the optic nerve only in glaucoma patients. In the optic nerve of rats with episcleral vein cauterization used as an animal model of glaucoma, the quantity of both gamma-synuclein mRNA and protein was decreased compared with the optic nerves of control anim...Continue Reading

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Citations

Jan 5, 2006·Cellular and Molecular Neurobiology·Irina SurguchevaAndrei Surguchov
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May 24, 2008·Journal of Molecular Neuroscience : MN·Irina Surgucheva, Andrei Surguchov
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May 25, 2012·Biochemistry·Irina SurguchevaAndrei Surguchov

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