Syphilis treatment and HIV infection in a population-based study of persons at high risk for sexually transmitted disease/HIV infection in Lima, Peru

Sexually Transmitted Diseases
Corey M LongNIMH Collaborative HIV/STD Prevention Trial Group

Abstract

The objective of this study was to characterize syphilis epidemiology and the relationship of HIV status and initial rapid plasma reagin (RPR) titer to syphilis treatment in Lima, Peru. We screened 1,261 individuals at high risk for sexually transmitted diseases for syphilis and HIV infection. Syphilis was treated with penicillin injection or doxycycline; treatment was repeated in unresponsive cases. : The prevalence of syphilis was 7.7%, 1-year incidence rate was 4.7%, and reinfection rate was 42.7%. The treatment success rate was 93.4% (71 of 76); those with initial RPR titers <or=1:8 were less often treated successfully (86.8% vs. 100%, P = 0.054) and required additional treatment more often (26.2% vs. 7.7%, P = 0.028) than those >or=1:16. HIV infection was associated with syphilis, prevalent in 15.6% and 3.7% of those with and without syphilis, respectively (P < 0.001), but did not affect treatment success (90.9% vs. 93.8%). Syphilis was common, associated with HIV infection, and less responsive to therapy in those with initial RPR titers <or=1:8. HIV infection did not affect syphilis treatment success rates.

References

Jan 9, 1992·The New England Journal of Medicine·S E LandisG G Koch
Apr 16, 1992·The New England Journal of Medicine·E W Hook, C M Marra
Jun 15, 1991·Annals of Internal Medicine·B RomanowskiE J Love
Mar 1, 1991·Journal of the American Academy of Dermatology·G TikjøbT Kobayasi
Sep 9, 1988·JAMA : the Journal of the American Medical Association·W E StammL Corey
Oct 1, 1971·The British Journal of Venereal Diseases·L Yogeswari, C W Chacko
Feb 12, 1996·Archives of Internal Medicine·A M YinnonR C Reichman
Aug 1, 1996·American Journal of Public Health·J SánchezK K Holmes
Feb 1, 1996·European Journal of Epidemiology·I ZapiolaG Muchinik
Mar 21, 1998·Emerging Infectious Diseases·G A SchmunisD Brandling-Bennett
Jul 11, 1998·JAMA : the Journal of the American Medical Association·T SchackerL Corey
Dec 19, 1998·Sexually Transmitted Diseases·M AugenbraunV Pope
Mar 7, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·N PressUNKNOWN Working Group on AIDS in Peru
Oct 9, 2001·International Journal of STD & AIDS·B T GohUNKNOWN European Branch of the International Union against Sexually Transmitted Infection and the European Office of the World Healt
May 15, 2003·Revista Panamericana De Salud Pública = Pan American Journal of Public Health·Nanci A SallesDalton F Chamone
Jun 7, 2003·Revista de saúde pública·María I CamejoMarcos Díaz
Jun 28, 2003·Tropical Medicine & International Health : TM & IH·Valquíria de Lima SoaresHermann Feldmeier
Oct 24, 2003·Sexually Transmitted Infections·P J Garcia, K K Holmes
Dec 30, 2003·Sexually Transmitted Diseases·Robert L CookMauro Schechter
Mar 10, 2004·International Journal of STD & AIDS·R ParkesU Laukamm-Josten

❮ Previous
Next ❯

Citations

Mar 8, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Bradley P Stoner
Apr 5, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nicola M Zetola, Jeffrey D Klausner
Dec 7, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Khalil G Ghanem, Kimberly A Workowski
Sep 8, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Damaris Fröhlich KnautePhilipp P Bosshard
Nov 27, 2009·Sexually Transmitted Diseases·Jonathan M SnowdenUNKNOWN NIMH HIV/STD Collaborative Intervention Trial
Nov 23, 2006·Sexually Transmitted Infections·P E CamposK K Holmes
Aug 28, 2010·Clinics in Dermatology·David Farhi, Nicolas Dupin
Mar 21, 2008·The Lancet Infectious Diseases·Kevin A FentonSally Blower
Jan 21, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·B-R WuS-Y Chang
Jul 6, 2013·Acta Microbiologica Et Immunologica Hungarica·John B Scythes, Colman M Jones
Jan 15, 2008·Current Opinion in Infectious Diseases·Kenneth A Katz, Jeffrey D Klausner
Apr 7, 2007·AIDS·UNKNOWN NIMH Collaborative HIV/STD Prevention Trial Group

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Nicola M Zetola, Jeffrey D Klausner
Clinical Microbiology Reviews
Rebecca E LaFond, S A Lukehart
© 2021 Meta ULC. All rights reserved