Syringe Injectable Electronics: Precise Targeted Delivery with Quantitative Input/Output Connectivity

Nano Letters
Guosong HongCharles M Lieber

Abstract

Syringe-injectable mesh electronics with tissue-like mechanical properties and open macroporous structures is an emerging powerful paradigm for mapping and modulating brain activity. Indeed, the ultraflexible macroporous structure has exhibited unprecedented minimal/noninvasiveness and the promotion of attractive interactions with neurons in chronic studies. These same structural features also pose new challenges and opportunities for precise targeted delivery in specific brain regions and quantitative input/output (I/O) connectivity needed for reliable electrical measurements. Here, we describe new results that address in a flexible manner both of these points. First, we have developed a controlled injection approach that maintains the extended mesh structure during the "blind" injection process, while also achieving targeted delivery with ca. 20 μm spatial precision. Optical and microcomputed tomography results from injections into tissue-like hydrogel, ex vivo brain tissue, and in vivo brains validate our basic approach and demonstrate its generality. Second, we present a general strategy to achieve up to 100% multichannel I/O connectivity using an automated conductive ink printing methodology to connect the mesh electronics...Continue Reading

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Citations

Dec 23, 2015·Chemical Reviews·Anqi Zhang, Charles M Lieber
Mar 24, 2016·Nano Letters·Xin GuanJosé Penuelas
Aug 30, 2016·Nature Methods·Tian-Ming FuCharles M Lieber
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