PMID: 16502653Mar 1, 2006Paper

Syringomyelia hydrodynamics: an in vitro study based on in vivo measurements

Journal of Biomechanical Engineering
Bryn MartinJohn N Oshinski

Abstract

A simplified in vitro model of the spinal canal, based on in vivo magnetic resonance imaging, was used to examine the hydrodynamics of the human spinal cord and subarachnoid space with syringomyelia. In vivo magnetic resonance imaging (MRI) measurements of subarachnoid (SAS) geometry and cerebrospinal fluid velocity were acquired in a patient with syringomyelia and used to aid in the in vitro model design and experiment. The in vitro model contained a fluid-filled coaxial elastic tube to represent a syrinx. A computer controlled pulsatile pump was used to subject the in vitro model to a CSF flow waveform representative of that measured in vivo. Fluid velocity was measured at three axial locations within the in vitro model using the same MRI scanner as the patient study. Pressure and syrinx wall motion measurements were conducted external to the MR scanner using the same model and flow input. Transducers measured unsteady pressure both in the SAS and intra-syrinx at four axial locations in the model A laser Doppler vibrometer recorded the syrinx wall motion at 18 axial locations and three polar positions. Results indicated that the peak-to-peak amplitude of the SAS flow waveform in vivo was approximately tenfold that of the syri...Continue Reading

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Citations

Dec 24, 2008·Journal of Biomechanical Engineering·Srdjan Cirovic
Dec 24, 2008·Journal of Biomechanical Engineering·Sumeet GuptaVartan Kurtcuoglu
Mar 12, 2009·Journal of Biomechanical Engineering·N S J ElliottA R Brodbelt
Apr 10, 2012·Journal of Biomechanical Engineering·N S J Elliott
Apr 10, 2012·Journal of Biomechanical Engineering·Srdjan Cirovic, Minsuok Kim
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Jan 29, 2009·IEEE Transactions on Bio-medical Engineering·Wojciech KalataFrancis Loth
Apr 26, 2011·Neurological Research·Nicholas ShafferFrancis Loth
Jul 25, 2015·Journal of Neurosurgery. Pediatrics·Analiz RodriguezDaniel E Couture
Nov 20, 2016·International Journal for Numerical Methods in Biomedical Engineering·Kartik JainKent-André Mardal
Nov 10, 2013·The Neuroradiology Journal·Ida N DrøsdalVictor Haughton
May 20, 2016·Neuroradiology·Aaron F StruckVictor M Haughton
Jan 24, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Bryn A MartinNikolaos Stergiopulos
Mar 11, 2018·BMC Veterinary Research·Srdjan CirovicClare Rusbridge
Jan 22, 2020·Fluids and Barriers of the CNS·Lucas R SassBryn A Martin
Aug 13, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kristina SonnabendKilian Weiss
Feb 18, 2014·Journal of Biomechanics·Anders HelgelandBjørn Anders Pettersson Reif

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