Syrinx size and duration of symptoms predict the pace of progressive myelopathy: retrospective analysis of 103 unoperated cases with craniocervical junction malformations and syringomyelia

Clinical Neurology and Neurosurgery
E I Bogdanov, E G Mendelevich

Abstract

the clinical course of syringomyelia associated with craniocervical junction abnormalities is variable. About half of the unoperated patients have benign course. This is difficult to explain on the basis of the present pathogenetic theories. Therefore, to understand the mechanism of syrinx progression better, we studied the value of syrinx size, syrinx morphology, and the syrinx/spinal cord size ratio in predicting the rate of progression and the severity of myelopathy in these patients. 103 adult patients with syringomyelia associated with Chiari 1 malformation and/or radiographic signs of underdeveloped posterior cranial fossa were clinically and MRI examined. Patients were subdivided according to the type of disease progression. Severity of neurological deficits, and MRI features (the extent of cerebellar tonsillar displacement, anteroposterior diameter of cavities, the spinal cord and cyst/cord ratio and the shape of cavities) were measured. a significant relationship was found between the mid-sagittal diameter of the syrinxes and the type of disease course; patients with short duration and rapid progression had the largest diameters of cavities, whereas patients with longer duration as well as with slow rate of progression...Continue Reading

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Citations

Sep 3, 2010·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Hugh J McMillanEnrique C G Ventureyra
Mar 3, 2006·Journal of Neurology·E I BogdanovE G Mendelevich
Aug 9, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Alessia ImperatoMichelangelo Gangemi
Jun 1, 2011·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Clarita MargaridoMrinalini Balki
Jul 11, 2003·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·A R Brodbelt, M A Stoodley
Sep 21, 2010·Brain : a Journal of Neurology·Samar M HatemDidier Bouhassira
Aug 3, 2011·Journal of Neurosurgery. Pediatrics·Jennifer StrahleCormac O Maher
Aug 3, 2011·Journal of Neurosurgery. Pediatrics·Jennifer StrahleCormac O Maher
Oct 23, 2012·Journal of Neurosurgery. Spine·Sarah J HemleyMarcus A Stoodley
Sep 27, 2015·Neurosurgery Clinics of North America·Elyne N KahnCormac O Maher
Nov 21, 2015·Journal of Neurosurgery. Pediatrics·I Jonathan PomeraniecJohn A Jane
Aug 29, 2003·Neurosurgery·Kazuhiko Kyoshima, Enver I Bogdanov
Nov 2, 2019·British Journal of Neurosurgery·Fawaz S Almotairi, Magnus Tisell
Sep 29, 2011·Journal of the Neurological Sciences·Ken SakushimaHidenao Sasaki
Apr 1, 2015·Pediatrics·Cormac O MaherUNKNOWN Section on Neurologic Surgery, American Academy of Pediatrics

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